Increased VEGF-A in solid type of lung adenocarcinoma reduces the patients’ survival

Abstract The histological classification of lung adenocarcinoma includes 5 types: lepidic, acinar, papillary, micropapillary and solid. The complex gene interactions and anticancer immune response of these types are not well known. The aim of this study was to reveal the survival rates, genetic alte...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Woon Yong Jung, Kyueng-Whan Min, Young Ha Oh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/060d330c8b6f44f8bd77e71740df6380
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:060d330c8b6f44f8bd77e71740df6380
record_format	dspace
spelling	oai:doaj.org-article:060d330c8b6f44f8bd77e71740df63802021-12-02T14:02:34ZIncreased VEGF-A in solid type of lung adenocarcinoma reduces the patients’ survival10.1038/s41598-020-79907-62045-2322https://doaj.org/article/060d330c8b6f44f8bd77e71740df63802021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79907-6https://doaj.org/toc/2045-2322Abstract The histological classification of lung adenocarcinoma includes 5 types: lepidic, acinar, papillary, micropapillary and solid. The complex gene interactions and anticancer immune response of these types are not well known. The aim of this study was to reveal the survival rates, genetic alterations and immune activities of the five histological types and provide treatment strategies. This study reviewed the histological findings of 517 patients with lung adenocarcinoma from The Cancer Genome Atlas (TCGA) database and classified them into five types. We performed gene set enrichment analysis (GSEA) and survival analysis according to the different types. We found six oncogenic gene sets that were higher in lung adenocarcinoma than in normal tissues. In the survival analysis of each type, the acinar type had a favorable prognosis, and the solid subtype had an unfavorable prognosis; however, the survival differences between the other types were not significant. Our study focused on the solid type, which had the poorest prognosis. The solid type was related to adaptive immune resistance associated with elevated CD8 T cells and high CD274 (encoding PD-L1) expression. In the pathway analyses, the solid type was significantly related to high vascular endothelial growth factor (VEGF)-A expression, reflecting tumor angiogenesis. Non-necrosis/low immune response affected by high VEGF-A was associated with worse prognosis. The solid type associated with high VEGF-A expression may contribute to the development of therapeutic strategies for lung adenocarcinoma.Woon Yong JungKyueng-Whan MinYoung Ha OhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Woon Yong Jung Kyueng-Whan Min Young Ha Oh Increased VEGF-A in solid type of lung adenocarcinoma reduces the patients’ survival
description	Abstract The histological classification of lung adenocarcinoma includes 5 types: lepidic, acinar, papillary, micropapillary and solid. The complex gene interactions and anticancer immune response of these types are not well known. The aim of this study was to reveal the survival rates, genetic alterations and immune activities of the five histological types and provide treatment strategies. This study reviewed the histological findings of 517 patients with lung adenocarcinoma from The Cancer Genome Atlas (TCGA) database and classified them into five types. We performed gene set enrichment analysis (GSEA) and survival analysis according to the different types. We found six oncogenic gene sets that were higher in lung adenocarcinoma than in normal tissues. In the survival analysis of each type, the acinar type had a favorable prognosis, and the solid subtype had an unfavorable prognosis; however, the survival differences between the other types were not significant. Our study focused on the solid type, which had the poorest prognosis. The solid type was related to adaptive immune resistance associated with elevated CD8 T cells and high CD274 (encoding PD-L1) expression. In the pathway analyses, the solid type was significantly related to high vascular endothelial growth factor (VEGF)-A expression, reflecting tumor angiogenesis. Non-necrosis/low immune response affected by high VEGF-A was associated with worse prognosis. The solid type associated with high VEGF-A expression may contribute to the development of therapeutic strategies for lung adenocarcinoma.
format	article
author	Woon Yong Jung Kyueng-Whan Min Young Ha Oh
author_facet	Woon Yong Jung Kyueng-Whan Min Young Ha Oh
author_sort	Woon Yong Jung
title	Increased VEGF-A in solid type of lung adenocarcinoma reduces the patients’ survival
title_short	Increased VEGF-A in solid type of lung adenocarcinoma reduces the patients’ survival
title_full	Increased VEGF-A in solid type of lung adenocarcinoma reduces the patients’ survival
title_fullStr	Increased VEGF-A in solid type of lung adenocarcinoma reduces the patients’ survival
title_full_unstemmed	Increased VEGF-A in solid type of lung adenocarcinoma reduces the patients’ survival
title_sort	increased vegf-a in solid type of lung adenocarcinoma reduces the patients’ survival
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/060d330c8b6f44f8bd77e71740df6380
work_keys_str_mv	AT woonyongjung increasedvegfainsolidtypeoflungadenocarcinomareducesthepatientssurvival AT kyuengwhanmin increasedvegfainsolidtypeoflungadenocarcinomareducesthepatientssurvival AT younghaoh increasedvegfainsolidtypeoflungadenocarcinomareducesthepatientssurvival
_version_	1718392063181979648

Increased VEGF-A in solid type of lung adenocarcinoma reduces the patients’ survival

Ejemplares similares