Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia

Abstract Chagas disease remains a major neglected disease in Colombia. We aimed to characterize Trypanosoma cruzi transmission networks in the Sierra Nevada de Santa Marta (SNSM) region, to shed light on disease ecology and help optimize control strategies. Triatomines were collected in rural commun...

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Autores principales:	Claribel Murillo-Solano, Jaime López-Domínguez, Rafael Gongora, Andres Rojas-Gulloso, Jose Usme-Ciro, Erick Perdomo-Balaguera, Claudia Herrera, Gabriel Parra-Henao, Eric Dumonteil
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/061200558ec540ed96db8ec9e58c4353
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spelling	oai:doaj.org-article:061200558ec540ed96db8ec9e58c43532021-12-02T17:52:32ZDiversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia10.1038/s41598-021-91783-22045-2322https://doaj.org/article/061200558ec540ed96db8ec9e58c43532021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91783-2https://doaj.org/toc/2045-2322Abstract Chagas disease remains a major neglected disease in Colombia. We aimed to characterize Trypanosoma cruzi transmission networks in the Sierra Nevada de Santa Marta (SNSM) region, to shed light on disease ecology and help optimize control strategies. Triatomines were collected in rural communities and analyzed for blood feeding sources, parasite diversity and gut microbiota composition through a metagenomic and deep sequencing approach. Triatoma dimidiata predominated, followed by Rhodnius prolixus, Triatoma maculata, Rhodnius pallescens, Panstrongylus geniculatus and Eratyrus cuspidatus. Twenty-two species were identified as blood sources, resulting in an integrated transmission network with extensive connectivity among sylvatic and domestic host species. Only TcI parasites were detected, predominantly from TcIb but TcIa was also reported. The close relatedness of T. cruzi strains further supported the lack of separate transmission cycles according to habitats or triatomine species. Triatomine microbiota varied according to species, developmental stage and T. cruzi infection. Bacterial families correlated with the presence/absence of T. cruzi were identified. In conclusion, we identified a domestic transmission cycle encompassing multiple vector species and tightly connected with sylvatic hosts in the SNSM region, rather than an isolated domestic transmission cycle. Therefore, integrated interventions targeting all vector species and their contact with humans should be considered.Claribel Murillo-SolanoJaime López-DomínguezRafael GongoraAndres Rojas-GullosoJose Usme-CiroErick Perdomo-BalagueraClaudia HerreraGabriel Parra-HenaoEric DumonteilNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claribel Murillo-Solano Jaime López-Domínguez Rafael Gongora Andres Rojas-Gulloso Jose Usme-Ciro Erick Perdomo-Balaguera Claudia Herrera Gabriel Parra-Henao Eric Dumonteil Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia
description	Abstract Chagas disease remains a major neglected disease in Colombia. We aimed to characterize Trypanosoma cruzi transmission networks in the Sierra Nevada de Santa Marta (SNSM) region, to shed light on disease ecology and help optimize control strategies. Triatomines were collected in rural communities and analyzed for blood feeding sources, parasite diversity and gut microbiota composition through a metagenomic and deep sequencing approach. Triatoma dimidiata predominated, followed by Rhodnius prolixus, Triatoma maculata, Rhodnius pallescens, Panstrongylus geniculatus and Eratyrus cuspidatus. Twenty-two species were identified as blood sources, resulting in an integrated transmission network with extensive connectivity among sylvatic and domestic host species. Only TcI parasites were detected, predominantly from TcIb but TcIa was also reported. The close relatedness of T. cruzi strains further supported the lack of separate transmission cycles according to habitats or triatomine species. Triatomine microbiota varied according to species, developmental stage and T. cruzi infection. Bacterial families correlated with the presence/absence of T. cruzi were identified. In conclusion, we identified a domestic transmission cycle encompassing multiple vector species and tightly connected with sylvatic hosts in the SNSM region, rather than an isolated domestic transmission cycle. Therefore, integrated interventions targeting all vector species and their contact with humans should be considered.
format	article
author	Claribel Murillo-Solano Jaime López-Domínguez Rafael Gongora Andres Rojas-Gulloso Jose Usme-Ciro Erick Perdomo-Balaguera Claudia Herrera Gabriel Parra-Henao Eric Dumonteil
author_facet	Claribel Murillo-Solano Jaime López-Domínguez Rafael Gongora Andres Rojas-Gulloso Jose Usme-Ciro Erick Perdomo-Balaguera Claudia Herrera Gabriel Parra-Henao Eric Dumonteil
author_sort	Claribel Murillo-Solano
title	Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia
title_short	Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia
title_full	Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia
title_fullStr	Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia
title_full_unstemmed	Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia
title_sort	diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and trypanosoma cruzi in the sierra nevada de santa marta in colombia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/061200558ec540ed96db8ec9e58c4353
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Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia

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