Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study

Abstract A reliable, non-invasive diagnostic method is needed for early detection and serial monitoring of cardiotoxicity, a well-known side effect of chemotherapy. This study aimed to assess the feasibility of T1-mapping cardiac magnetic resonance imaging (CMR) for evaluating subclinical myocardial...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoo Jin Hong, Heae Surng Park, Jeffrey Kihyun Park, Kyunghwa Han, Chul Hwan Park, Tai Kyung Kim, Sae Jong Yoo, Ji Yeon Lee, Pan Ki Kim, Jin Hur, Hye-Jeong Lee, Young Jin Kim, Young Joo Suh, Mun Young Paek, Byoung Wook Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06139a1fd4ca4381befb9ddb7f6637e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:06139a1fd4ca4381befb9ddb7f6637e7
record_format	dspace
spelling	oai:doaj.org-article:06139a1fd4ca4381befb9ddb7f6637e72021-12-02T16:06:12ZEarly Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study10.1038/s41598-017-02627-x2045-2322https://doaj.org/article/06139a1fd4ca4381befb9ddb7f6637e72017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02627-xhttps://doaj.org/toc/2045-2322Abstract A reliable, non-invasive diagnostic method is needed for early detection and serial monitoring of cardiotoxicity, a well-known side effect of chemotherapy. This study aimed to assess the feasibility of T1-mapping cardiac magnetic resonance imaging (CMR) for evaluating subclinical myocardial changes in a doxorubicin-induced cardiotoxicity rabbit model. Adult male New Zealand White rabbits were injected twice-weekly with doxorubicin and subjected to CMR on a clinical 3T MR system before and every 2–4 weeks post-drug administration. Native T1 and extracellular volume (ECV) values were measured at six mid-left ventricle (LV) and specific LV lesions. Histological assessments evaluated myocardial injury and fibrosis. Three pre-model and 11 post-model animals were included. Myocardial injury was observed from 3 weeks. Mean LV myocardium ECV values increased significantly from week 3 before LV ejection fraction decreases (week 6), and ECVs of the RV upper/lower insertion sites and papillary muscle exceeded those of the LV. The mean native T1 value in the mid-LV increased significantly increased from week 6, and LV myocardium ECV correlated strongly with the degree of fibrosis (r = 0.979, p < 0.001). Myocardial T1 mapping, particularly ECV values, reliably and non-invasively detected early cardiotoxicity, allowing serial monitoring of chemotherapy-induced cardiotoxicity.Yoo Jin HongHeae Surng ParkJeffrey Kihyun ParkKyunghwa HanChul Hwan ParkTai Kyung KimSae Jong YooJi Yeon LeePan Ki KimJin HurHye-Jeong LeeYoung Jin KimYoung Joo SuhMun Young PaekByoung Wook ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoo Jin Hong Heae Surng Park Jeffrey Kihyun Park Kyunghwa Han Chul Hwan Park Tai Kyung Kim Sae Jong Yoo Ji Yeon Lee Pan Ki Kim Jin Hur Hye-Jeong Lee Young Jin Kim Young Joo Suh Mun Young Paek Byoung Wook Choi Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study
description	Abstract A reliable, non-invasive diagnostic method is needed for early detection and serial monitoring of cardiotoxicity, a well-known side effect of chemotherapy. This study aimed to assess the feasibility of T1-mapping cardiac magnetic resonance imaging (CMR) for evaluating subclinical myocardial changes in a doxorubicin-induced cardiotoxicity rabbit model. Adult male New Zealand White rabbits were injected twice-weekly with doxorubicin and subjected to CMR on a clinical 3T MR system before and every 2–4 weeks post-drug administration. Native T1 and extracellular volume (ECV) values were measured at six mid-left ventricle (LV) and specific LV lesions. Histological assessments evaluated myocardial injury and fibrosis. Three pre-model and 11 post-model animals were included. Myocardial injury was observed from 3 weeks. Mean LV myocardium ECV values increased significantly from week 3 before LV ejection fraction decreases (week 6), and ECVs of the RV upper/lower insertion sites and papillary muscle exceeded those of the LV. The mean native T1 value in the mid-LV increased significantly increased from week 6, and LV myocardium ECV correlated strongly with the degree of fibrosis (r = 0.979, p < 0.001). Myocardial T1 mapping, particularly ECV values, reliably and non-invasively detected early cardiotoxicity, allowing serial monitoring of chemotherapy-induced cardiotoxicity.
format	article
author	Yoo Jin Hong Heae Surng Park Jeffrey Kihyun Park Kyunghwa Han Chul Hwan Park Tai Kyung Kim Sae Jong Yoo Ji Yeon Lee Pan Ki Kim Jin Hur Hye-Jeong Lee Young Jin Kim Young Joo Suh Mun Young Paek Byoung Wook Choi
author_facet	Yoo Jin Hong Heae Surng Park Jeffrey Kihyun Park Kyunghwa Han Chul Hwan Park Tai Kyung Kim Sae Jong Yoo Ji Yeon Lee Pan Ki Kim Jin Hur Hye-Jeong Lee Young Jin Kim Young Joo Suh Mun Young Paek Byoung Wook Choi
author_sort	Yoo Jin Hong
title	Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study
title_short	Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study
title_full	Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study
title_fullStr	Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study
title_full_unstemmed	Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study
title_sort	early detection and serial monitoring of anthracycline-induced cardiotoxicity using t1-mapping cardiac magnetic resonance imaging: an animal study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/06139a1fd4ca4381befb9ddb7f6637e7
work_keys_str_mv	AT yoojinhong earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT heaesurngpark earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT jeffreykihyunpark earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT kyunghwahan earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT chulhwanpark earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT taikyungkim earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT saejongyoo earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT jiyeonlee earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT pankikim earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT jinhur earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT hyejeonglee earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT youngjinkim earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT youngjoosuh earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT munyoungpaek earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy AT byoungwookchoi earlydetectionandserialmonitoringofanthracyclineinducedcardiotoxicityusingt1mappingcardiacmagneticresonanceimagingananimalstudy
_version_	1718385067016847360

Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study

Ejemplares similares