X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice
Abstract Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to deve...
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Nature Portfolio
2017
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oai:doaj.org-article:0613f94baea44e24921db9e16033a4752021-12-02T15:06:26ZX-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice10.1038/s41598-017-00489-x2045-2322https://doaj.org/article/0613f94baea44e24921db9e16033a4752017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00489-xhttps://doaj.org/toc/2045-2322Abstract Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Within this letter, we propose to exploit X-ray dark-field imaging as a novel diagnostic tool for the detection of lung cancer on projection radiographs. Here, we demonstrate in living mice bearing lung tumors, that X-ray dark-field radiography provides significantly improved lung tumor detection rates without increasing the number of false-positives, especially in the case of small and superimposed nodules, when compared to conventional absorption-based imaging. While this method still needs to be adapted to larger mammals and finally humans, the technique presented here can already serve as a valuable tool in evaluating novel lung cancer therapies, tested in mice and other small animal models.Kai SchererAndre YaroshenkoDeniz Ali BölükbasLukas B. GromannKatharina HellbachFelix G. MeinelMargarita BraunagelJens von BergOliver EickelbergMaximilian F. ReiserFranz PfeifferSilke MeinersJulia HerzenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
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Medicine R Science Q |
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Medicine R Science Q Kai Scherer Andre Yaroshenko Deniz Ali Bölükbas Lukas B. Gromann Katharina Hellbach Felix G. Meinel Margarita Braunagel Jens von Berg Oliver Eickelberg Maximilian F. Reiser Franz Pfeiffer Silke Meiners Julia Herzen X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice |
| description |
Abstract Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Within this letter, we propose to exploit X-ray dark-field imaging as a novel diagnostic tool for the detection of lung cancer on projection radiographs. Here, we demonstrate in living mice bearing lung tumors, that X-ray dark-field radiography provides significantly improved lung tumor detection rates without increasing the number of false-positives, especially in the case of small and superimposed nodules, when compared to conventional absorption-based imaging. While this method still needs to be adapted to larger mammals and finally humans, the technique presented here can already serve as a valuable tool in evaluating novel lung cancer therapies, tested in mice and other small animal models. |
| format |
article |
| author |
Kai Scherer Andre Yaroshenko Deniz Ali Bölükbas Lukas B. Gromann Katharina Hellbach Felix G. Meinel Margarita Braunagel Jens von Berg Oliver Eickelberg Maximilian F. Reiser Franz Pfeiffer Silke Meiners Julia Herzen |
| author_facet |
Kai Scherer Andre Yaroshenko Deniz Ali Bölükbas Lukas B. Gromann Katharina Hellbach Felix G. Meinel Margarita Braunagel Jens von Berg Oliver Eickelberg Maximilian F. Reiser Franz Pfeiffer Silke Meiners Julia Herzen |
| author_sort |
Kai Scherer |
| title |
X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice |
| title_short |
X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice |
| title_full |
X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice |
| title_fullStr |
X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice |
| title_full_unstemmed |
X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice |
| title_sort |
x-ray dark-field radiography - in-vivo diagnosis of lung cancer in mice |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/0613f94baea44e24921db9e16033a475 |
| work_keys_str_mv |
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| _version_ |
1718388429039861760 |