A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae

Whole-cell models hold great promise for fundamental and translational biology, but genome-scale modelling of signalling networks has been a challenge. Here, the authors present a genome-scale, mechanistic and executable model of the network controlling and executing the S. cerevisiae cell cycle.

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Detalles Bibliográficos
Autores principales: Ulrike Münzner, Edda Klipp, Marcus Krantz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
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Acceso en línea:https://doaj.org/article/0615cfea666e4b4e822c127ef0947045
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Sumario:Whole-cell models hold great promise for fundamental and translational biology, but genome-scale modelling of signalling networks has been a challenge. Here, the authors present a genome-scale, mechanistic and executable model of the network controlling and executing the S. cerevisiae cell cycle.