A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae

Whole-cell models hold great promise for fundamental and translational biology, but genome-scale modelling of signalling networks has been a challenge. Here, the authors present a genome-scale, mechanistic and executable model of the network controlling and executing the S. cerevisiae cell cycle.

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Autores principales: Ulrike Münzner, Edda Klipp, Marcus Krantz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0615cfea666e4b4e822c127ef0947045
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spelling oai:doaj.org-article:0615cfea666e4b4e822c127ef09470452021-12-02T15:35:12ZA comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae10.1038/s41467-019-08903-w2041-1723https://doaj.org/article/0615cfea666e4b4e822c127ef09470452019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08903-whttps://doaj.org/toc/2041-1723Whole-cell models hold great promise for fundamental and translational biology, but genome-scale modelling of signalling networks has been a challenge. Here, the authors present a genome-scale, mechanistic and executable model of the network controlling and executing the S. cerevisiae cell cycle.Ulrike MünznerEdda KlippMarcus KrantzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ulrike Münzner
Edda Klipp
Marcus Krantz
A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae
description Whole-cell models hold great promise for fundamental and translational biology, but genome-scale modelling of signalling networks has been a challenge. Here, the authors present a genome-scale, mechanistic and executable model of the network controlling and executing the S. cerevisiae cell cycle.
format article
author Ulrike Münzner
Edda Klipp
Marcus Krantz
author_facet Ulrike Münzner
Edda Klipp
Marcus Krantz
author_sort Ulrike Münzner
title A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae
title_short A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae
title_full A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae
title_fullStr A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae
title_full_unstemmed A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae
title_sort comprehensive, mechanistically detailed, and executable model of the cell division cycle in saccharomyces cerevisiae
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/0615cfea666e4b4e822c127ef0947045
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