Maternal control of visceral asymmetry evolution in Astyanax cavefish

Abstract The direction of visceral organ asymmetry is highly conserved during vertebrate evolution with heart development biased to the left and pancreas and liver development restricted to opposing sides of the midline. Here we show that reversals in visceral organ asymmetry have evolved in Astyana...

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Autores principales:	Li Ma, Mandy Ng, Janet Shi, Aniket V. Gore, Daniel Castranova, Brant M. Weinstein, William R. Jeffery
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06165d6c202f43fd980bc9efe850fed2
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spelling	oai:doaj.org-article:06165d6c202f43fd980bc9efe850fed22021-12-02T16:50:22ZMaternal control of visceral asymmetry evolution in Astyanax cavefish10.1038/s41598-021-89702-62045-2322https://doaj.org/article/06165d6c202f43fd980bc9efe850fed22021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89702-6https://doaj.org/toc/2045-2322Abstract The direction of visceral organ asymmetry is highly conserved during vertebrate evolution with heart development biased to the left and pancreas and liver development restricted to opposing sides of the midline. Here we show that reversals in visceral organ asymmetry have evolved in Astyanax mexicanus, a teleost species with interfertile surface-dwelling (surface fish) and cave-dwelling (cavefish) forms. Visceral organ asymmetry is conventional in surface fish but some cavefish have evolved reversals in heart, liver, and pancreas development. Corresponding changes in the normally left-sided expression of the Nodal-Pitx2/Lefty signaling system are also present in the cavefish lateral plate mesoderm (LPM). The Nodal antagonists lefty1 (lft1) and lefty2 (lft2), which confine Nodal signaling to the left LPM, are expressed in most surface fish, however, lft2, but not lft1, expression is absent during somitogenesis of most cavefish. Despite this difference, multiple lines of evidence suggested that evolutionary changes in L-R patterning are controlled upstream of Nodal-Pitx2/Lefty signaling. Accordingly, reciprocal hybridization of cavefish and surface fish showed that modifications of heart asymmetry are present in hybrids derived from cavefish mothers but not from surface fish mothers. The results indicate that changes in visceral asymmetry during cavefish evolution are influenced by maternal genetic effects.Li MaMandy NgJanet ShiAniket V. GoreDaniel CastranovaBrant M. WeinsteinWilliam R. JefferyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Ma Mandy Ng Janet Shi Aniket V. Gore Daniel Castranova Brant M. Weinstein William R. Jeffery Maternal control of visceral asymmetry evolution in Astyanax cavefish
description	Abstract The direction of visceral organ asymmetry is highly conserved during vertebrate evolution with heart development biased to the left and pancreas and liver development restricted to opposing sides of the midline. Here we show that reversals in visceral organ asymmetry have evolved in Astyanax mexicanus, a teleost species with interfertile surface-dwelling (surface fish) and cave-dwelling (cavefish) forms. Visceral organ asymmetry is conventional in surface fish but some cavefish have evolved reversals in heart, liver, and pancreas development. Corresponding changes in the normally left-sided expression of the Nodal-Pitx2/Lefty signaling system are also present in the cavefish lateral plate mesoderm (LPM). The Nodal antagonists lefty1 (lft1) and lefty2 (lft2), which confine Nodal signaling to the left LPM, are expressed in most surface fish, however, lft2, but not lft1, expression is absent during somitogenesis of most cavefish. Despite this difference, multiple lines of evidence suggested that evolutionary changes in L-R patterning are controlled upstream of Nodal-Pitx2/Lefty signaling. Accordingly, reciprocal hybridization of cavefish and surface fish showed that modifications of heart asymmetry are present in hybrids derived from cavefish mothers but not from surface fish mothers. The results indicate that changes in visceral asymmetry during cavefish evolution are influenced by maternal genetic effects.
format	article
author	Li Ma Mandy Ng Janet Shi Aniket V. Gore Daniel Castranova Brant M. Weinstein William R. Jeffery
author_facet	Li Ma Mandy Ng Janet Shi Aniket V. Gore Daniel Castranova Brant M. Weinstein William R. Jeffery
author_sort	Li Ma
title	Maternal control of visceral asymmetry evolution in Astyanax cavefish
title_short	Maternal control of visceral asymmetry evolution in Astyanax cavefish
title_full	Maternal control of visceral asymmetry evolution in Astyanax cavefish
title_fullStr	Maternal control of visceral asymmetry evolution in Astyanax cavefish
title_full_unstemmed	Maternal control of visceral asymmetry evolution in Astyanax cavefish
title_sort	maternal control of visceral asymmetry evolution in astyanax cavefish
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06165d6c202f43fd980bc9efe850fed2
work_keys_str_mv	AT lima maternalcontrolofvisceralasymmetryevolutioninastyanaxcavefish AT mandyng maternalcontrolofvisceralasymmetryevolutioninastyanaxcavefish AT janetshi maternalcontrolofvisceralasymmetryevolutioninastyanaxcavefish AT aniketvgore maternalcontrolofvisceralasymmetryevolutioninastyanaxcavefish AT danielcastranova maternalcontrolofvisceralasymmetryevolutioninastyanaxcavefish AT brantmweinstein maternalcontrolofvisceralasymmetryevolutioninastyanaxcavefish AT williamrjeffery maternalcontrolofvisceralasymmetryevolutioninastyanaxcavefish
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Maternal control of visceral asymmetry evolution in Astyanax cavefish

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