Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery

The interaction of nanoparticles with a range of biomolecules once they have been injected within the body can affect their performance. Here, the authors demonstrate that squalene nanomaterials conjugated with anticancer drugs can interact with lipoproteins and can be used to target cancer cells.

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Autores principales:	Dunja Sobot, Simona Mura, Semen O. Yesylevskyy, Laura Dalbin, Fanny Cayre, Guillaume Bort, Julie Mougin, Didier Desmaële, Sinda Lepetre-Mouelhi, Grégory Pieters, Bohdan Andreiuk, Andrey S. Klymchenko, Jean-Louis Paul, Christophe Ramseyer, Patrick Couvreur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/061aa937c3464c1992e959529c5f6d40
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spelling	oai:doaj.org-article:061aa937c3464c1992e959529c5f6d402021-12-02T15:37:06ZConjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery10.1038/ncomms156782041-1723https://doaj.org/article/061aa937c3464c1992e959529c5f6d402017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15678https://doaj.org/toc/2041-1723The interaction of nanoparticles with a range of biomolecules once they have been injected within the body can affect their performance. Here, the authors demonstrate that squalene nanomaterials conjugated with anticancer drugs can interact with lipoproteins and can be used to target cancer cells.Dunja SobotSimona MuraSemen O. YesylevskyyLaura DalbinFanny CayreGuillaume BortJulie MouginDidier DesmaëleSinda Lepetre-MouelhiGrégory PietersBohdan AndreiukAndrey S. KlymchenkoJean-Louis PaulChristophe RamseyerPatrick CouvreurNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dunja Sobot Simona Mura Semen O. Yesylevskyy Laura Dalbin Fanny Cayre Guillaume Bort Julie Mougin Didier Desmaële Sinda Lepetre-Mouelhi Grégory Pieters Bohdan Andreiuk Andrey S. Klymchenko Jean-Louis Paul Christophe Ramseyer Patrick Couvreur Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery
description	The interaction of nanoparticles with a range of biomolecules once they have been injected within the body can affect their performance. Here, the authors demonstrate that squalene nanomaterials conjugated with anticancer drugs can interact with lipoproteins and can be used to target cancer cells.
format	article
author	Dunja Sobot Simona Mura Semen O. Yesylevskyy Laura Dalbin Fanny Cayre Guillaume Bort Julie Mougin Didier Desmaële Sinda Lepetre-Mouelhi Grégory Pieters Bohdan Andreiuk Andrey S. Klymchenko Jean-Louis Paul Christophe Ramseyer Patrick Couvreur
author_facet	Dunja Sobot Simona Mura Semen O. Yesylevskyy Laura Dalbin Fanny Cayre Guillaume Bort Julie Mougin Didier Desmaële Sinda Lepetre-Mouelhi Grégory Pieters Bohdan Andreiuk Andrey S. Klymchenko Jean-Louis Paul Christophe Ramseyer Patrick Couvreur
author_sort	Dunja Sobot
title	Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery
title_short	Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery
title_full	Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery
title_fullStr	Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery
title_full_unstemmed	Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery
title_sort	conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/061aa937c3464c1992e959529c5f6d40
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Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery

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