Renal functional reserve and tubular function in patents with type 2 diabetes mellitus

Aim. To study renal functional reserve and partial functions in patents with type 2 diabetes mellitus in the absence of renal lesionsMaterials and methods. We examined 42 patients (17 men and 24 women) aged 38-69 (mean 49.8?8.3) years with DM2 4.6?2.6 yr in duration.Control group comprised 32 pract...

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Autores principales:	Dilyara Makhmutrievna Khakimova, Adelya Nailevna Maksudova, Il'dar Gazimdzhanovich Salikhov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2011
Materias:	diabetic nephropathy hyperfiltration renal functional reserve tubular dysfunction Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/061d71618231468b94ca15f7e93e4082
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spelling	oai:doaj.org-article:061d71618231468b94ca15f7e93e40822021-11-14T09:00:16ZRenal functional reserve and tubular function in patents with type 2 diabetes mellitus2072-03512072-037810.14341/2072-0351-5641https://doaj.org/article/061d71618231468b94ca15f7e93e40822011-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5641https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To study renal functional reserve and partial functions in patents with type 2 diabetes mellitus in the absence of renal lesionsMaterials and methods. We examined 42 patients (17 men and 24 women) aged 38-69 (mean 49.8?8.3) years with DM2 4.6?2.6 yr in duration.Control group comprised 32 practically healthy subjects. Intrarenal hemodynamics was estimated from RFR values. Ethanolamine, uric acid, Ca,and P levels were measured in sera and 24-hr urine; daily excretion of ammonia and aminonitrogen in the urine was determined. Results. The patients were divided into 2 groups based on the results of RFR measurement. FRF remained unaltered in 21 patients (mean 60.7?27.6%)and decreased in the absence of filtration reserve in 20 (-25.8?23.4%). Correlation analysis revealed the relationship of lipid metabolism and abdominalobesity with the renal tubular function and intraglomerular hemodynamics. Conclusion. Examination of DM2 patients without clinical and laboratory signs of renal lesions revealed compromised function of all nephron compartments,viz. intraglomerular hypertension, impaired stability of renal cell membranes, and tubular dysfunction. The latter is related to hemodynamic disturbances.Dilyara Makhmutrievna KhakimovaAdelya Nailevna MaksudovaIl'dar Gazimdzhanovich SalikhovEndocrinology Research Centrearticlediabetic nephropathyhyperfiltrationrenal functional reservetubular dysfunctionNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 2, Pp 82-85 (2011)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetic nephropathy hyperfiltration renal functional reserve tubular dysfunction Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetic nephropathy hyperfiltration renal functional reserve tubular dysfunction Nutritional diseases. Deficiency diseases RC620-627 Dilyara Makhmutrievna Khakimova Adelya Nailevna Maksudova Il'dar Gazimdzhanovich Salikhov Renal functional reserve and tubular function in patents with type 2 diabetes mellitus
description	Aim. To study renal functional reserve and partial functions in patents with type 2 diabetes mellitus in the absence of renal lesionsMaterials and methods. We examined 42 patients (17 men and 24 women) aged 38-69 (mean 49.8?8.3) years with DM2 4.6?2.6 yr in duration.Control group comprised 32 practically healthy subjects. Intrarenal hemodynamics was estimated from RFR values. Ethanolamine, uric acid, Ca,and P levels were measured in sera and 24-hr urine; daily excretion of ammonia and aminonitrogen in the urine was determined. Results. The patients were divided into 2 groups based on the results of RFR measurement. FRF remained unaltered in 21 patients (mean 60.7?27.6%)and decreased in the absence of filtration reserve in 20 (-25.8?23.4%). Correlation analysis revealed the relationship of lipid metabolism and abdominalobesity with the renal tubular function and intraglomerular hemodynamics. Conclusion. Examination of DM2 patients without clinical and laboratory signs of renal lesions revealed compromised function of all nephron compartments,viz. intraglomerular hypertension, impaired stability of renal cell membranes, and tubular dysfunction. The latter is related to hemodynamic disturbances.
format	article
author	Dilyara Makhmutrievna Khakimova Adelya Nailevna Maksudova Il'dar Gazimdzhanovich Salikhov
author_facet	Dilyara Makhmutrievna Khakimova Adelya Nailevna Maksudova Il'dar Gazimdzhanovich Salikhov
author_sort	Dilyara Makhmutrievna Khakimova
title	Renal functional reserve and tubular function in patents with type 2 diabetes mellitus
title_short	Renal functional reserve and tubular function in patents with type 2 diabetes mellitus
title_full	Renal functional reserve and tubular function in patents with type 2 diabetes mellitus
title_fullStr	Renal functional reserve and tubular function in patents with type 2 diabetes mellitus
title_full_unstemmed	Renal functional reserve and tubular function in patents with type 2 diabetes mellitus
title_sort	renal functional reserve and tubular function in patents with type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2011
url	https://doaj.org/article/061d71618231468b94ca15f7e93e4082
work_keys_str_mv	AT dilyaramakhmutrievnakhakimova renalfunctionalreserveandtubularfunctioninpatentswithtype2diabetesmellitus AT adelyanailevnamaksudova renalfunctionalreserveandtubularfunctioninpatentswithtype2diabetesmellitus AT ildargazimdzhanovichsalikhov renalfunctionalreserveandtubularfunctioninpatentswithtype2diabetesmellitus
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Renal functional reserve and tubular function in patents with type 2 diabetes mellitus

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