Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion

Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion

John O Mason III,1,2 Shyam A Patel,1 Richard M Feist,1,2 Michael A Albert Jr,1,2 Carrie Huisingh,1 Gerald McGwin Jr,1,3 Martin L Thomley1,2 1Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL, USA; 2Retina Consultants of Alabama, Callahan Eye Foundation Hospital,...

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Autores principales: Mason lll JO, Patel SA, Feist RM, Albert Jr MA, Huisingh C, McGwin Jr G, Thomley ML
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/06229ad3bad34edbbf2379b82a332fee
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spelling oai:doaj.org-article:06229ad3bad34edbbf2379b82a332fee2021-12-02T01:43:24ZOcular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion1177-5483https://doaj.org/article/06229ad3bad34edbbf2379b82a332fee2015-06-01T00:00:00Zhttp://www.dovepress.com/ocular-neovascularization-in-eyes-with-a-central-retinal-artery-occlus-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483John O Mason III,1,2 Shyam A Patel,1 Richard M Feist,1,2 Michael A Albert Jr,1,2 Carrie Huisingh,1 Gerald McGwin Jr,1,3 Martin L Thomley1,2 1Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL, USA; 2Retina Consultants of Alabama, Callahan Eye Foundation Hospital, Birmingham, AL, USA; 3Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA Purpose: To investigate the ocular neovascularization (ONV) rate in eyes with a branch retinal artery occlusion (BRAO) or a central retinal artery occlusion (CRAO), and to study factors that may influence the ONV rate secondary to CRAO.Methods: This was a retrospective case series of consecutive patients (286 total eyes: 83 CRAOs and 203 BRAOs) who were diagnosed with a retinal artery occlusion from 1998 to 2013 at the Retina Consultants of Alabama and University of Alabama at Birmingham, Birmingham, AL, USA. Generalized estimating equations were used to evaluate the association between hypothesized risk factors and ONV development.Results: Twelve (14.5%) of the 83 eyes with a CRAO developed ONV. Eleven of 12 eyes (91.7%) had iris neovascularization, ten of 12 eyes (83.3%) had neovascular glaucoma, and two of 12 eyes (16.7%) had neovascularization of the optic disc. The average time for ONV development secondary to CRAO was 30.7 days, ranging from the date of presentation to 137 days. Only two (<1.0%) of the 203 eyes with a BRAO developed iris neovascularization. Diabetes mellitus type 2 was a risk factor for ONV development following a CRAO with an adjusted odds ratio of 5.2 (95% confidence interval: 1.4–19.8) (P=0.02).Conclusion: ONV is an important complication of CRAO and is a less-frequent complication of BRAO. Patients with a CRAO, especially those with diabetes mellitus type 2, should be closely monitored for the first 6 months for ONV. Keywords: neovascularization, neovascular glaucoma, retinal artery occlusion, central retinal artery occlusion, branch retinal artery occlusion, diabetes mellitusMason lll JOPatel SAFeist RMAlbert Jr MAHuisingh CMcGwin Jr GThomley MLDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 995-1000 (2015)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Mason lll JO
Patel SA
Feist RM
Albert Jr MA
Huisingh C
McGwin Jr G
Thomley ML
Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
description John O Mason III,1,2 Shyam A Patel,1 Richard M Feist,1,2 Michael A Albert Jr,1,2 Carrie Huisingh,1 Gerald McGwin Jr,1,3 Martin L Thomley1,2 1Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL, USA; 2Retina Consultants of Alabama, Callahan Eye Foundation Hospital, Birmingham, AL, USA; 3Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA Purpose: To investigate the ocular neovascularization (ONV) rate in eyes with a branch retinal artery occlusion (BRAO) or a central retinal artery occlusion (CRAO), and to study factors that may influence the ONV rate secondary to CRAO.Methods: This was a retrospective case series of consecutive patients (286 total eyes: 83 CRAOs and 203 BRAOs) who were diagnosed with a retinal artery occlusion from 1998 to 2013 at the Retina Consultants of Alabama and University of Alabama at Birmingham, Birmingham, AL, USA. Generalized estimating equations were used to evaluate the association between hypothesized risk factors and ONV development.Results: Twelve (14.5%) of the 83 eyes with a CRAO developed ONV. Eleven of 12 eyes (91.7%) had iris neovascularization, ten of 12 eyes (83.3%) had neovascular glaucoma, and two of 12 eyes (16.7%) had neovascularization of the optic disc. The average time for ONV development secondary to CRAO was 30.7 days, ranging from the date of presentation to 137 days. Only two (<1.0%) of the 203 eyes with a BRAO developed iris neovascularization. Diabetes mellitus type 2 was a risk factor for ONV development following a CRAO with an adjusted odds ratio of 5.2 (95% confidence interval: 1.4–19.8) (P=0.02).Conclusion: ONV is an important complication of CRAO and is a less-frequent complication of BRAO. Patients with a CRAO, especially those with diabetes mellitus type 2, should be closely monitored for the first 6 months for ONV. Keywords: neovascularization, neovascular glaucoma, retinal artery occlusion, central retinal artery occlusion, branch retinal artery occlusion, diabetes mellitus
format article
author Mason lll JO
Patel SA
Feist RM
Albert Jr MA
Huisingh C
McGwin Jr G
Thomley ML
author_facet Mason lll JO
Patel SA
Feist RM
Albert Jr MA
Huisingh C
McGwin Jr G
Thomley ML
author_sort Mason lll JO
title Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
title_short Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
title_full Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
title_fullStr Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
title_full_unstemmed Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
title_sort ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/06229ad3bad34edbbf2379b82a332fee
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AT feistrm ocularneovascularizationineyeswithacentralretinalarteryocclusionorabranchretinalarterynbspocclusion
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AT mcgwinjrg ocularneovascularizationineyeswithacentralretinalarteryocclusionorabranchretinalarterynbspocclusion
AT thomleyml ocularneovascularizationineyeswithacentralretinalarteryocclusionorabranchretinalarterynbspocclusion
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