Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors

Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors

Chur Chin1, In Kyeom Kim2, Dong Yoon Lim3, Ki Suk Kim4, Hyang Ae Lee4, Eun Joo Kim41Department of Pediatrics, Fatima Hospital, Daegu, Korea; 2Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Korea; 3Department of Pharmacology, School of Medicine, Chosun Universit...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Chur Chin, In Kyeom Kim, Dong Yoon Lim, et al
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2010
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/0622ade21d2c4081be545c34c33893d7
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:0622ade21d2c4081be545c34c33893d7
record_format dspace
spelling oai:doaj.org-article:0622ade21d2c4081be545c34c33893d72021-12-02T03:05:08ZGold nanoparticle–choline complexes can block nicotinic acetylcholine receptors1176-91141178-2013https://doaj.org/article/0622ade21d2c4081be545c34c33893d72010-04-01T00:00:00Zhttp://www.dovepress.com/gold-nanoparticlendashcholine-complexes-can-block-nicotinic-acetylchol-a4275https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Chur Chin1, In Kyeom Kim2, Dong Yoon Lim3, Ki Suk Kim4, Hyang Ae Lee4, Eun Joo Kim41Department of Pediatrics, Fatima Hospital, Daegu, Korea; 2Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Korea; 3Department of Pharmacology, School of Medicine, Chosun University, Gwangju, Korea; 4Korea Institute of Toxicology, Daejeon, KoreaAbstract: We identified a novel class of direct ion-channel blockers of ligand-gated ion channels called the gold nanoparticle–choline complex. Negatively charged gold nanoparticles (1.4 nm) block ion pores by binding to the sulfur group of the cysteine loop of nicotinic acetylcholine receptors (nAChRs), and currents evoked by acetylcholine (Ach) can break these bonds. The current evoked by ACh in nAChRs was blocked directly in ion pores by the gold nanoparticle–choline complex. In adrenal-gland perfusion studies, the complex also blocked nAChRs by diminishing catecholamine release by about 75%. An in vivo study showed muscle relaxation in rats after injection of the complex. These results will foster the application of gold nanoparticles as a direct ion-channel blocker. Keywords: negatively charged gold nanoparticle, choline, gold–sulfur bond, nicotinic acetylcholine receptor, direct ion-channel blocker Chur ChinIn Kyeom KimDong Yoon Limet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 315-321 (2010)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Chur Chin
In Kyeom Kim
Dong Yoon Lim
et al
Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors
description Chur Chin1, In Kyeom Kim2, Dong Yoon Lim3, Ki Suk Kim4, Hyang Ae Lee4, Eun Joo Kim41Department of Pediatrics, Fatima Hospital, Daegu, Korea; 2Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Korea; 3Department of Pharmacology, School of Medicine, Chosun University, Gwangju, Korea; 4Korea Institute of Toxicology, Daejeon, KoreaAbstract: We identified a novel class of direct ion-channel blockers of ligand-gated ion channels called the gold nanoparticle–choline complex. Negatively charged gold nanoparticles (1.4 nm) block ion pores by binding to the sulfur group of the cysteine loop of nicotinic acetylcholine receptors (nAChRs), and currents evoked by acetylcholine (Ach) can break these bonds. The current evoked by ACh in nAChRs was blocked directly in ion pores by the gold nanoparticle–choline complex. In adrenal-gland perfusion studies, the complex also blocked nAChRs by diminishing catecholamine release by about 75%. An in vivo study showed muscle relaxation in rats after injection of the complex. These results will foster the application of gold nanoparticles as a direct ion-channel blocker. Keywords: negatively charged gold nanoparticle, choline, gold–sulfur bond, nicotinic acetylcholine receptor, direct ion-channel blocker
format article
author Chur Chin
In Kyeom Kim
Dong Yoon Lim
et al
author_facet Chur Chin
In Kyeom Kim
Dong Yoon Lim
et al
author_sort Chur Chin
title Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors
title_short Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors
title_full Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors
title_fullStr Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors
title_full_unstemmed Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors
title_sort gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/0622ade21d2c4081be545c34c33893d7
work_keys_str_mv AT churchin goldnanoparticleampndashcholinecomplexescanblocknicotinicacetylcholinereceptors
AT inkyeomkim goldnanoparticleampndashcholinecomplexescanblocknicotinicacetylcholinereceptors
AT dongyoonlim goldnanoparticleampndashcholinecomplexescanblocknicotinicacetylcholinereceptors
AT etal goldnanoparticleampndashcholinecomplexescanblocknicotinicacetylcholinereceptors
_version_ 1718401960416116736

Ejemplares similares