Association of salivary C-reactive protein with the obesity measures and markers in children

Vaithinathan Selvaraju,1 Jeganathan Ramesh Babu,1,2 Thangiah Geetha1,21Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL, USA; 2Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL, USAObjective: Overweight and obesity is a pro-in...

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Autores principales:	Selvaraju V, Babu JR, Geetha T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	childhood obesity non-invasive inflammation cytokines Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0624fde61ca548b3bc18895ae17aa097
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spelling	oai:doaj.org-article:0624fde61ca548b3bc18895ae17aa0972021-12-02T03:50:25ZAssociation of salivary C-reactive protein with the obesity measures and markers in children1178-7007https://doaj.org/article/0624fde61ca548b3bc18895ae17aa0972019-07-01T00:00:00Zhttps://www.dovepress.com/association-of-salivary-c-reactive-protein-with-the-obesity-measures-a-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Vaithinathan Selvaraju,1 Jeganathan Ramesh Babu,1,2 Thangiah Geetha1,21Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL, USA; 2Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL, USAObjective: Overweight and obesity is a pro-inflammatory state. This study aimed to examine the level of the salivary obesity markers in normal weight (NW) and overweight/obese (OW/OB) children, association with the obesity measures and the interrelations between the biomarkers.Subjects and methods: Seventy-six children (40 normal weight and 36 overweight/obese) were recruited for this study. Body weight, height, and waist circumference measurement were obtained. The saliva sample was collected from all the participants. According to the Center for Disease Control and Prevention (CDC), the participants were classified into the normal weight or overweight/obese depending upon the body mass index (BMI) percentile ranking. The obesity panel of salivary markers resistin, C-C Motif Chemokine Ligand 2 (CCL2)/monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), complement factor D, and interleukin-10 (IL-10) were determined using human magnetic Luminex performance assay. The receiver operating characteristics (ROC) analysis was used to determine the area under the curve (AUC) to identify the best salivary biomarker in children. Linear regression and Pearson’s correlation analyses to determine the association between the parameters.Results: The obesity biomarkers resistin, MCP-1, TNF-α, IL-6 and CRP were significantly high in overweight/obese compared to normal weight. Salivary CRP (AUC: 0.866, 95% CI: 0.780–0.952; p<0.0001) showed superiority area under ROC curves with good discriminatory power than resistin, MCP-1, TNF-α, and IL-6. BMI z-score, WC z-score, and WHtR z-score showed a significant association (p<0.0001) with CRP. The CRP significantly (p<0.0001) correlated with resistin, CCL2/MCP-1, TNF-α, IL-6, and IL-10 by linear regression and Pearson’s correlation analysis.Conclusion: Increased level of salivary CRP in children may be considered as a non-invasive marker for childhood obesity for detection of the risk factors for the development of metabolic dysregulation.Keywords: childhood obesity, non-invasive, inflammation, body mass indexSelvaraju VBabu JRGeetha TDove Medical Pressarticlechildhood obesitynon-invasiveinflammationcytokinesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1239-1247 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	childhood obesity non-invasive inflammation cytokines Specialties of internal medicine RC581-951
spellingShingle	childhood obesity non-invasive inflammation cytokines Specialties of internal medicine RC581-951 Selvaraju V Babu JR Geetha T Association of salivary C-reactive protein with the obesity measures and markers in children
description	Vaithinathan Selvaraju,1 Jeganathan Ramesh Babu,1,2 Thangiah Geetha1,21Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL, USA; 2Boshell Metabolic Diseases and Diabetes Program, Auburn University, Auburn, AL, USAObjective: Overweight and obesity is a pro-inflammatory state. This study aimed to examine the level of the salivary obesity markers in normal weight (NW) and overweight/obese (OW/OB) children, association with the obesity measures and the interrelations between the biomarkers.Subjects and methods: Seventy-six children (40 normal weight and 36 overweight/obese) were recruited for this study. Body weight, height, and waist circumference measurement were obtained. The saliva sample was collected from all the participants. According to the Center for Disease Control and Prevention (CDC), the participants were classified into the normal weight or overweight/obese depending upon the body mass index (BMI) percentile ranking. The obesity panel of salivary markers resistin, C-C Motif Chemokine Ligand 2 (CCL2)/monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), complement factor D, and interleukin-10 (IL-10) were determined using human magnetic Luminex performance assay. The receiver operating characteristics (ROC) analysis was used to determine the area under the curve (AUC) to identify the best salivary biomarker in children. Linear regression and Pearson’s correlation analyses to determine the association between the parameters.Results: The obesity biomarkers resistin, MCP-1, TNF-α, IL-6 and CRP were significantly high in overweight/obese compared to normal weight. Salivary CRP (AUC: 0.866, 95% CI: 0.780–0.952; p<0.0001) showed superiority area under ROC curves with good discriminatory power than resistin, MCP-1, TNF-α, and IL-6. BMI z-score, WC z-score, and WHtR z-score showed a significant association (p<0.0001) with CRP. The CRP significantly (p<0.0001) correlated with resistin, CCL2/MCP-1, TNF-α, IL-6, and IL-10 by linear regression and Pearson’s correlation analysis.Conclusion: Increased level of salivary CRP in children may be considered as a non-invasive marker for childhood obesity for detection of the risk factors for the development of metabolic dysregulation.Keywords: childhood obesity, non-invasive, inflammation, body mass index
format	article
author	Selvaraju V Babu JR Geetha T
author_facet	Selvaraju V Babu JR Geetha T
author_sort	Selvaraju V
title	Association of salivary C-reactive protein with the obesity measures and markers in children
title_short	Association of salivary C-reactive protein with the obesity measures and markers in children
title_full	Association of salivary C-reactive protein with the obesity measures and markers in children
title_fullStr	Association of salivary C-reactive protein with the obesity measures and markers in children
title_full_unstemmed	Association of salivary C-reactive protein with the obesity measures and markers in children
title_sort	association of salivary c-reactive protein with the obesity measures and markers in children
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/0624fde61ca548b3bc18895ae17aa097
work_keys_str_mv	AT selvarajuv associationofsalivarycreactiveproteinwiththeobesitymeasuresandmarkersinchildren AT babujr associationofsalivarycreactiveproteinwiththeobesitymeasuresandmarkersinchildren AT geethat associationofsalivarycreactiveproteinwiththeobesitymeasuresandmarkersinchildren
_version_	1718401590537224192

Association of salivary C-reactive protein with the obesity measures and markers in children

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