Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands

Lung cancer is a complex disease associated with gene mutations, particularly mutations of Kirsten Rat Sarcoma Viral Oncogene Homolog (<i>KRAS</i>) and epidermal growth factor receptor (<i>EGFR</i>). Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the...

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Autores principales:	Sarah Sayed Hassanein, Sherif Abdelaziz Ibrahim, Ahmed Lotfy Abdel-Mawgood
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	epidermal growth factor receptor (EGFR) microRNA (miRNA) therapeutic targets diagnostic markers signaling pathways oncogenes Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/062be9940e06408eb93c6e7ce563f5f4
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spelling	oai:doaj.org-article:062be9940e06408eb93c6e7ce563f5f42021-11-25T17:57:15ZCell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands10.3390/ijms2222124961422-00671661-6596https://doaj.org/article/062be9940e06408eb93c6e7ce563f5f42021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12496https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Lung cancer is a complex disease associated with gene mutations, particularly mutations of Kirsten Rat Sarcoma Viral Oncogene Homolog (<i>KRAS</i>) and epidermal growth factor receptor (<i>EGFR</i>). Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major types of lung cancer. The former includes most lung cancers (85%) and are commonly associated with EGFR mutations. Several EGFR-tyrosine kinase inhibitors (EGFR-TKIs), including erlotinib, gefitinib, and osimertinib, are effective therapeutic agents in <i>EGFR</i>-mutated NSCLC. However, their effectiveness is limited by the development (acquired) or presence of intrinsic drug resistance. MicroRNAs (miRNAs) are key gene regulators that play a profound role in the development and outcomes for NSCLC via their role as oncogenes or oncosuppressors. The regulatory role of miRNA-dependent <i>EGFR</i> crosstalk depends on <i>EGFR</i> signaling pathway, including Rat Sarcoma/Rapidly Accelerated Fibrosarcoma/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase 1/2 (Ras/Raf/MEK/ERK1/2), Signal Transducer and Activator of Transcription (STAT), Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-kB), phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), Janus kinase 1 (JAK1), and growth factor receptor-bound protein 2 (GRB2). Dysregulated expression of miRNAs affects sensitivity to treatment with EGFR-TKIs. Thus, abnormalities in miRNA-dependent EGFR crosstalk can be used as diagnostic and prognostic markers, as well as therapeutic targets in NSCLC. In this review, we present an overview of miRNA-dependent EGFR expression regulation, which modulates the behavior and progression of NSCLC.Sarah Sayed HassaneinSherif Abdelaziz IbrahimAhmed Lotfy Abdel-MawgoodMDPI AGarticleepidermal growth factor receptor (EGFR)microRNA (miRNA)therapeutic targetsdiagnostic markerssignaling pathwaysoncogenesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12496, p 12496 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epidermal growth factor receptor (EGFR) microRNA (miRNA) therapeutic targets diagnostic markers signaling pathways oncogenes Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	epidermal growth factor receptor (EGFR) microRNA (miRNA) therapeutic targets diagnostic markers signaling pathways oncogenes Biology (General) QH301-705.5 Chemistry QD1-999 Sarah Sayed Hassanein Sherif Abdelaziz Ibrahim Ahmed Lotfy Abdel-Mawgood Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands
description	Lung cancer is a complex disease associated with gene mutations, particularly mutations of Kirsten Rat Sarcoma Viral Oncogene Homolog (<i>KRAS</i>) and epidermal growth factor receptor (<i>EGFR</i>). Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major types of lung cancer. The former includes most lung cancers (85%) and are commonly associated with EGFR mutations. Several EGFR-tyrosine kinase inhibitors (EGFR-TKIs), including erlotinib, gefitinib, and osimertinib, are effective therapeutic agents in <i>EGFR</i>-mutated NSCLC. However, their effectiveness is limited by the development (acquired) or presence of intrinsic drug resistance. MicroRNAs (miRNAs) are key gene regulators that play a profound role in the development and outcomes for NSCLC via their role as oncogenes or oncosuppressors. The regulatory role of miRNA-dependent <i>EGFR</i> crosstalk depends on <i>EGFR</i> signaling pathway, including Rat Sarcoma/Rapidly Accelerated Fibrosarcoma/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase 1/2 (Ras/Raf/MEK/ERK1/2), Signal Transducer and Activator of Transcription (STAT), Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-kB), phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), Janus kinase 1 (JAK1), and growth factor receptor-bound protein 2 (GRB2). Dysregulated expression of miRNAs affects sensitivity to treatment with EGFR-TKIs. Thus, abnormalities in miRNA-dependent EGFR crosstalk can be used as diagnostic and prognostic markers, as well as therapeutic targets in NSCLC. In this review, we present an overview of miRNA-dependent EGFR expression regulation, which modulates the behavior and progression of NSCLC.
format	article
author	Sarah Sayed Hassanein Sherif Abdelaziz Ibrahim Ahmed Lotfy Abdel-Mawgood
author_facet	Sarah Sayed Hassanein Sherif Abdelaziz Ibrahim Ahmed Lotfy Abdel-Mawgood
author_sort	Sarah Sayed Hassanein
title	Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands
title_short	Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands
title_full	Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands
title_fullStr	Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands
title_full_unstemmed	Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands
title_sort	cell behavior of non-small cell lung cancer is at egfr and micrornas hands
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/062be9940e06408eb93c6e7ce563f5f4
work_keys_str_mv	AT sarahsayedhassanein cellbehaviorofnonsmallcelllungcancerisategfrandmicrornashands AT sherifabdelazizibrahim cellbehaviorofnonsmallcelllungcancerisategfrandmicrornashands AT ahmedlotfyabdelmawgood cellbehaviorofnonsmallcelllungcancerisategfrandmicrornashands
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Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands

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