Pheochromocytoma and Adrenocortical Carcinoma: Morphological Characteristics in Endoscopic Ultrasound Imaging
Purpose Pheochromocytoma (PCC) and adrenocortical carcinoma (ACC) are two rare endocrine diseases. Early diagnosis is crucial to significantly reduce morbidity and mortality. In this study, we used endoscopic ultrasound (EUS) for high-resol...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Georg Thieme Verlag KG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/062d010f0d614d74b2ec378b993dfe85 |
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| Sumario: | Purpose Pheochromocytoma (PCC) and adrenocortical carcinoma (ACC) are two
rare endocrine diseases. Early diagnosis is crucial to significantly reduce
morbidity and mortality. In this study, we used endoscopic ultrasound (EUS) for
high-resolution imaging to investigate the endosonographic morphology pattern of
PCC and ACC.
Materials and Methods This retrospective cohort study included 58
PCC/ACC lesions diagnosed by EUS imaging at two tertiary care centers
between 1997 and 2015. The following groups were defined by histology or by the
presence of a pheochromocytoma-associated syndrome without histological proof:
bPCC (benign PCC), mPCC (malignant PCC), and ACC.
Results In our cohort, mPCC tended to be larger at the time of diagnosis
(n=5; 39.9±41.9 mm) than bPCC (n=46;
27.3 ±20.8 mm, P=0.548). ACC lesions were
significantly larger (n=7; 50.6±14.8 mm) than bPCC and
mPCC (n=51; 28.5±23.3 mm, P=0.002). In EUS, bPCC
and ACC lesions frequently appeared to have a round shape and nodular structure.
bPCC and ACC tended to be more hyperechoic (P=0.112 and P=0.558,
respectively) and heterogeneous (P=0.501 and P=0.098,
respectively) than mPCC. Compared to PCC, ACC did not show high hyperperfusion
(P=0.022). In contrast to adenoma, all tumor entities showed
hypo-/anechoic areas within the tumor (P<0.05).
Conclusion No significant differences in EUS morphology were found to
reliably distinguish benign from malignant PCC and ACC lesions. However, EUS may
be a reasonable alternative or complementary method to conventional imaging
techniques for the early detection of these tumor entities. |
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