Pheochromocytoma and Adrenocortical Carcinoma: Morphological Characteristics in Endoscopic Ultrasound Imaging

Purpose Pheochromocytoma (PCC) and adrenocortical carcinoma (ACC) are two rare endocrine diseases. Early diagnosis is crucial to significantly reduce morbidity and mortality. In this study, we used endoscopic ultrasound (EUS) for high-resol...

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Autores principales:	Neslihan Özkul, Peter Herbert Kann
Formato:	article
Lenguaje:	EN
Publicado:	Georg Thieme Verlag KG 2021
Materias:	ultrasound adrenal gland tumor Medicine R Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/062d010f0d614d74b2ec378b993dfe85
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spelling	oai:doaj.org-article:062d010f0d614d74b2ec378b993dfe852021-11-18T00:06:51ZPheochromocytoma and Adrenocortical Carcinoma: Morphological Characteristics in Endoscopic Ultrasound Imaging2509-596X2199-715210.1055/a-1626-1678https://doaj.org/article/062d010f0d614d74b2ec378b993dfe852021-08-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/a-1626-1678https://doaj.org/toc/2509-596Xhttps://doaj.org/toc/2199-7152Purpose Pheochromocytoma (PCC) and adrenocortical carcinoma (ACC) are two rare endocrine diseases. Early diagnosis is crucial to significantly reduce morbidity and mortality. In this study, we used endoscopic ultrasound (EUS) for high-resolution imaging to investigate the endosonographic morphology pattern of PCC and ACC. Materials and Methods This retrospective cohort study included 58 PCC/ACC lesions diagnosed by EUS imaging at two tertiary care centers between 1997 and 2015. The following groups were defined by histology or by the presence of a pheochromocytoma-associated syndrome without histological proof: bPCC (benign PCC), mPCC (malignant PCC), and ACC. Results In our cohort, mPCC tended to be larger at the time of diagnosis (n=5; 39.9±41.9 mm) than bPCC (n=46; 27.3 ±20.8 mm, P=0.548). ACC lesions were significantly larger (n=7; 50.6±14.8 mm) than bPCC and mPCC (n=51; 28.5±23.3 mm, P=0.002). In EUS, bPCC and ACC lesions frequently appeared to have a round shape and nodular structure. bPCC and ACC tended to be more hyperechoic (P=0.112 and P=0.558, respectively) and heterogeneous (P=0.501 and P=0.098, respectively) than mPCC. Compared to PCC, ACC did not show high hyperperfusion (P=0.022). In contrast to adenoma, all tumor entities showed hypo-/anechoic areas within the tumor (P<0.05). Conclusion No significant differences in EUS morphology were found to reliably distinguish benign from malignant PCC and ACC lesions. However, EUS may be a reasonable alternative or complementary method to conventional imaging techniques for the early detection of these tumor entities.Neslihan ÖzkulPeter Herbert KannGeorg Thieme Verlag KGarticleultrasoundadrenal glandtumorMedicineRMedical physics. Medical radiology. Nuclear medicineR895-920ENUltrasound International Open, Vol 07, Iss 02, Pp E64-E70 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ultrasound adrenal gland tumor Medicine R Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	ultrasound adrenal gland tumor Medicine R Medical physics. Medical radiology. Nuclear medicine R895-920 Neslihan Özkul Peter Herbert Kann Pheochromocytoma and Adrenocortical Carcinoma: Morphological Characteristics in Endoscopic Ultrasound Imaging
description	Purpose Pheochromocytoma (PCC) and adrenocortical carcinoma (ACC) are two rare endocrine diseases. Early diagnosis is crucial to significantly reduce morbidity and mortality. In this study, we used endoscopic ultrasound (EUS) for high-resolution imaging to investigate the endosonographic morphology pattern of PCC and ACC. Materials and Methods This retrospective cohort study included 58 PCC/ACC lesions diagnosed by EUS imaging at two tertiary care centers between 1997 and 2015. The following groups were defined by histology or by the presence of a pheochromocytoma-associated syndrome without histological proof: bPCC (benign PCC), mPCC (malignant PCC), and ACC. Results In our cohort, mPCC tended to be larger at the time of diagnosis (n=5; 39.9±41.9 mm) than bPCC (n=46; 27.3 ±20.8 mm, P=0.548). ACC lesions were significantly larger (n=7; 50.6±14.8 mm) than bPCC and mPCC (n=51; 28.5±23.3 mm, P=0.002). In EUS, bPCC and ACC lesions frequently appeared to have a round shape and nodular structure. bPCC and ACC tended to be more hyperechoic (P=0.112 and P=0.558, respectively) and heterogeneous (P=0.501 and P=0.098, respectively) than mPCC. Compared to PCC, ACC did not show high hyperperfusion (P=0.022). In contrast to adenoma, all tumor entities showed hypo-/anechoic areas within the tumor (P<0.05). Conclusion No significant differences in EUS morphology were found to reliably distinguish benign from malignant PCC and ACC lesions. However, EUS may be a reasonable alternative or complementary method to conventional imaging techniques for the early detection of these tumor entities.
format	article
author	Neslihan Özkul Peter Herbert Kann
author_facet	Neslihan Özkul Peter Herbert Kann
author_sort	Neslihan Özkul
title	Pheochromocytoma and Adrenocortical Carcinoma: Morphological Characteristics in Endoscopic Ultrasound Imaging
title_short	Pheochromocytoma and Adrenocortical Carcinoma: Morphological Characteristics in Endoscopic Ultrasound Imaging
title_full	Pheochromocytoma and Adrenocortical Carcinoma: Morphological Characteristics in Endoscopic Ultrasound Imaging
title_fullStr	Pheochromocytoma and Adrenocortical Carcinoma: Morphological Characteristics in Endoscopic Ultrasound Imaging
title_full_unstemmed	Pheochromocytoma and Adrenocortical Carcinoma: Morphological Characteristics in Endoscopic Ultrasound Imaging
title_sort	pheochromocytoma and adrenocortical carcinoma: morphological characteristics in endoscopic ultrasound imaging
publisher	Georg Thieme Verlag KG
publishDate	2021
url	https://doaj.org/article/062d010f0d614d74b2ec378b993dfe85
work_keys_str_mv	AT neslihanozkul pheochromocytomaandadrenocorticalcarcinomamorphologicalcharacteristicsinendoscopicultrasoundimaging AT peterherbertkann pheochromocytomaandadrenocorticalcarcinomamorphologicalcharacteristicsinendoscopicultrasoundimaging
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Pheochromocytoma and Adrenocortical Carcinoma: Morphological Characteristics in Endoscopic Ultrasound Imaging

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