<italic toggle="yes">Klebsiella pneumoniae</italic> Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering

<italic toggle="yes">Klebsiella pneumoniae</italic> Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering

ABSTRACT The emergence of Klebsiella pneumoniae carbapenemases (KPCs), β-lactamases that inactivate “last-line” antibiotics such as imipenem, represents a major challenge to contemporary antibiotic therapies. The combination of ceftazidime (CAZ) and avibactam (AVI), a potent β-lactamase inhibitor, r...

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Autores principales: Melissa D. Barnes, Marisa L. Winkler, Magdalena A. Taracila, Malcolm G. Page, Eric Desarbre, Barry N. Kreiswirth, Ryan K. Shields, Minh-Hong Nguyen, Cornelius Clancy, Brad Spellberg, Krisztina M. Papp-Wallace, Robert A. Bonomo
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
KPC-2
avibactam
beta-lactam
beta-lactamase
carbapenemase
ceftazidime
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/062e9bcecccb41e7b5c7a796418333b1
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