Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

Altered gut microbiome and exacerbation of symptoms at times of psychological stress are feature characteristics of Crohn’s disease. Here authors show in a mouse model that psychological stress impairs IL-22-dependent protective immunity of the ileal mucosa, which allows invasive bacteria to colonis...

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Main Authors: Christopher R. Shaler, Alexandra A. Parco, Wael Elhenawy, Jasmeen Dourka, Jennifer Jury, Elena F. Verdu, Brian K. Coombes
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/062f55d29a194e71a96d5f94c1c3d3f7
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spelling oai:doaj.org-article:062f55d29a194e71a96d5f94c1c3d3f72021-11-21T12:33:57ZPsychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts10.1038/s41467-021-26992-42041-1723https://doaj.org/article/062f55d29a194e71a96d5f94c1c3d3f72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26992-4https://doaj.org/toc/2041-1723Altered gut microbiome and exacerbation of symptoms at times of psychological stress are feature characteristics of Crohn’s disease. Here authors show in a mouse model that psychological stress impairs IL-22-dependent protective immunity of the ileal mucosa, which allows invasive bacteria to colonise the gut.Christopher R. ShalerAlexandra A. ParcoWael ElhenawyJasmeen DourkaJennifer JuryElena F. VerduBrian K. CoombesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Christopher R. Shaler
Alexandra A. Parco
Wael Elhenawy
Jasmeen Dourka
Jennifer Jury
Elena F. Verdu
Brian K. Coombes
Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts
description Altered gut microbiome and exacerbation of symptoms at times of psychological stress are feature characteristics of Crohn’s disease. Here authors show in a mouse model that psychological stress impairs IL-22-dependent protective immunity of the ileal mucosa, which allows invasive bacteria to colonise the gut.
format article
author Christopher R. Shaler
Alexandra A. Parco
Wael Elhenawy
Jasmeen Dourka
Jennifer Jury
Elena F. Verdu
Brian K. Coombes
author_facet Christopher R. Shaler
Alexandra A. Parco
Wael Elhenawy
Jasmeen Dourka
Jennifer Jury
Elena F. Verdu
Brian K. Coombes
author_sort Christopher R. Shaler
title Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts
title_short Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts
title_full Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts
title_fullStr Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts
title_full_unstemmed Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts
title_sort psychological stress impairs il22-driven protective gut mucosal immunity against colonising pathobionts
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/062f55d29a194e71a96d5f94c1c3d3f7
work_keys_str_mv AT christopherrshaler psychologicalstressimpairsil22drivenprotectivegutmucosalimmunityagainstcolonisingpathobionts
AT alexandraaparco psychologicalstressimpairsil22drivenprotectivegutmucosalimmunityagainstcolonisingpathobionts
AT waelelhenawy psychologicalstressimpairsil22drivenprotectivegutmucosalimmunityagainstcolonisingpathobionts
AT jasmeendourka psychologicalstressimpairsil22drivenprotectivegutmucosalimmunityagainstcolonisingpathobionts
AT jenniferjury psychologicalstressimpairsil22drivenprotectivegutmucosalimmunityagainstcolonisingpathobionts
AT elenafverdu psychologicalstressimpairsil22drivenprotectivegutmucosalimmunityagainstcolonisingpathobionts
AT briankcoombes psychologicalstressimpairsil22drivenprotectivegutmucosalimmunityagainstcolonisingpathobionts
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