Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

Altered gut microbiome and exacerbation of symptoms at times of psychological stress are feature characteristics of Crohn’s disease. Here authors show in a mouse model that psychological stress impairs IL-22-dependent protective immunity of the ileal mucosa, which allows invasive bacteria to colonis...

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Autores principales: Christopher R. Shaler, Alexandra A. Parco, Wael Elhenawy, Jasmeen Dourka, Jennifer Jury, Elena F. Verdu, Brian K. Coombes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/062f55d29a194e71a96d5f94c1c3d3f7
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