Engineered niches support the development of human dendritic cells in humanized mice

Classical human dendritic cells (cDCs) are rare sentinel cells specialized in regulating adaptive immunity. Here, the authors show that expression of membrane bound FLT3L, along with stem cell factor (SCF) and CXCL12 in stromal cells induces specification of pre/AS-DCs, type 1 and type2 cDC from hae...

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Autores principales:	Giorgio Anselmi, Kristine Vaivode, Charles-Antoine Dutertre, Pierre Bourdely, Yoann Missolo-Koussou, Evan Newell, Oliver Hickman, Kristie Wood, Alka Saxena, Julie Helft, Florent Ginhoux, Pierre Guermonprez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/063014aa8c3746a095f182dc864bceda
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spelling	oai:doaj.org-article:063014aa8c3746a095f182dc864bceda2021-12-02T16:49:44ZEngineered niches support the development of human dendritic cells in humanized mice10.1038/s41467-020-15937-y2041-1723https://doaj.org/article/063014aa8c3746a095f182dc864bceda2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15937-yhttps://doaj.org/toc/2041-1723Classical human dendritic cells (cDCs) are rare sentinel cells specialized in regulating adaptive immunity. Here, the authors show that expression of membrane bound FLT3L, along with stem cell factor (SCF) and CXCL12 in stromal cells induces specification of pre/AS-DCs, type 1 and type2 cDC from haematopoietic stem cells.Giorgio AnselmiKristine VaivodeCharles-Antoine DutertrePierre BourdelyYoann Missolo-KoussouEvan NewellOliver HickmanKristie WoodAlka SaxenaJulie HelftFlorent GinhouxPierre GuermonprezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giorgio Anselmi Kristine Vaivode Charles-Antoine Dutertre Pierre Bourdely Yoann Missolo-Koussou Evan Newell Oliver Hickman Kristie Wood Alka Saxena Julie Helft Florent Ginhoux Pierre Guermonprez Engineered niches support the development of human dendritic cells in humanized mice
description	Classical human dendritic cells (cDCs) are rare sentinel cells specialized in regulating adaptive immunity. Here, the authors show that expression of membrane bound FLT3L, along with stem cell factor (SCF) and CXCL12 in stromal cells induces specification of pre/AS-DCs, type 1 and type2 cDC from haematopoietic stem cells.
format	article
author	Giorgio Anselmi Kristine Vaivode Charles-Antoine Dutertre Pierre Bourdely Yoann Missolo-Koussou Evan Newell Oliver Hickman Kristie Wood Alka Saxena Julie Helft Florent Ginhoux Pierre Guermonprez
author_facet	Giorgio Anselmi Kristine Vaivode Charles-Antoine Dutertre Pierre Bourdely Yoann Missolo-Koussou Evan Newell Oliver Hickman Kristie Wood Alka Saxena Julie Helft Florent Ginhoux Pierre Guermonprez
author_sort	Giorgio Anselmi
title	Engineered niches support the development of human dendritic cells in humanized mice
title_short	Engineered niches support the development of human dendritic cells in humanized mice
title_full	Engineered niches support the development of human dendritic cells in humanized mice
title_fullStr	Engineered niches support the development of human dendritic cells in humanized mice
title_full_unstemmed	Engineered niches support the development of human dendritic cells in humanized mice
title_sort	engineered niches support the development of human dendritic cells in humanized mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/063014aa8c3746a095f182dc864bceda
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Engineered niches support the development of human dendritic cells in humanized mice

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