High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles

Abstract This study examined acute molecular responses to concurrent exercise involving different muscles. Eight men participated in a randomized crossover-trial with two sessions, one where they performed interval cycling followed by upper body resistance exercise (ER-Arm), and one with upper body...

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Autores principales:	Marcus Moberg, William Apró, Igor Cervenka, Björn Ekblom, Gerrit van Hall, Hans-Christer Holmberg, Jorge L. Ruas, Eva Blomstrand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06362132992943c3be5970aa6e96d42f
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spelling	oai:doaj.org-article:06362132992943c3be5970aa6e96d42f2021-12-02T13:17:42ZHigh-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles10.1038/s41598-021-85733-12045-2322https://doaj.org/article/06362132992943c3be5970aa6e96d42f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85733-1https://doaj.org/toc/2045-2322Abstract This study examined acute molecular responses to concurrent exercise involving different muscles. Eight men participated in a randomized crossover-trial with two sessions, one where they performed interval cycling followed by upper body resistance exercise (ER-Arm), and one with upper body resistance exercise only (R-Arm). Biopsies were taken from the triceps prior to and immediately, 90- and 180-min following exercise. Immediately after resistance exercise, the elevation in S6K1 activity was smaller and the 4E-BP1:eIF4E interaction greater in ER-Arm, but this acute attenuation disappeared during recovery. The protein synthetic rate in triceps was greater following exercise than at rest, with no difference between trials. The level of PGC-1α1 mRNA increased to greater extent in ER-Arm than R-Arm after 90 min of recovery, as was PGC-1α4 mRNA after both 90 and 180 min. Levels of MuRF-1 mRNA was unchanged in R-Arm, but elevated during recovery in ER-Arm, whereas MAFbx mRNA levels increased slightly in both trials. RNA sequencing in a subgroup of subjects revealed 862 differently expressed genes with ER-Arm versus R-Arm during recovery. These findings suggest that leg cycling prior to arm resistance exercise causes systemic changes that potentiate induction of specific genes in the triceps, without compromising the anabolic response.Marcus MobergWilliam ApróIgor CervenkaBjörn EkblomGerrit van HallHans-Christer HolmbergJorge L. RuasEva BlomstrandNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcus Moberg William Apró Igor Cervenka Björn Ekblom Gerrit van Hall Hans-Christer Holmberg Jorge L. Ruas Eva Blomstrand High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles
description	Abstract This study examined acute molecular responses to concurrent exercise involving different muscles. Eight men participated in a randomized crossover-trial with two sessions, one where they performed interval cycling followed by upper body resistance exercise (ER-Arm), and one with upper body resistance exercise only (R-Arm). Biopsies were taken from the triceps prior to and immediately, 90- and 180-min following exercise. Immediately after resistance exercise, the elevation in S6K1 activity was smaller and the 4E-BP1:eIF4E interaction greater in ER-Arm, but this acute attenuation disappeared during recovery. The protein synthetic rate in triceps was greater following exercise than at rest, with no difference between trials. The level of PGC-1α1 mRNA increased to greater extent in ER-Arm than R-Arm after 90 min of recovery, as was PGC-1α4 mRNA after both 90 and 180 min. Levels of MuRF-1 mRNA was unchanged in R-Arm, but elevated during recovery in ER-Arm, whereas MAFbx mRNA levels increased slightly in both trials. RNA sequencing in a subgroup of subjects revealed 862 differently expressed genes with ER-Arm versus R-Arm during recovery. These findings suggest that leg cycling prior to arm resistance exercise causes systemic changes that potentiate induction of specific genes in the triceps, without compromising the anabolic response.
format	article
author	Marcus Moberg William Apró Igor Cervenka Björn Ekblom Gerrit van Hall Hans-Christer Holmberg Jorge L. Ruas Eva Blomstrand
author_facet	Marcus Moberg William Apró Igor Cervenka Björn Ekblom Gerrit van Hall Hans-Christer Holmberg Jorge L. Ruas Eva Blomstrand
author_sort	Marcus Moberg
title	High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles
title_short	High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles
title_full	High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles
title_fullStr	High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles
title_full_unstemmed	High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles
title_sort	high-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06362132992943c3be5970aa6e96d42f
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High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles

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