Functional disability is related to serum chemerin levels in rheumatoid arthritis

Abstract Adipokines, especially chemerin, can interact with cytokines and other molecules in inflammation. To date, there is insufficient information regarding a possible correlation between functional disability and chemerin and other pro-inflammatory molecules in rheumatoid arthritis (RA). To iden...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maria Luisa Vazquez-Villegas, Jorge I. Gamez-Nava, A. Miriam Saldaña-Cruz, Alfredo Celis, Esther N. Sanchez-Rodriguez, Edsaul Emilio Perez-Guerrero, Melissa Ramirez-Villafaña, Cesar Arturo Nava-Valdivia, Betsabe Contreras-Haro, Jose C. Vasquez-Jimenez, Juan M. Ponce-Guarneros, Ana K. Barocio-Ramirez, Sergio Cerpa-Cruz, Miriam F. Alcaraz-Lopez, Laura Gonzalez-Lopez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/063671eb263042d2ba62f1392ed3d4a2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:063671eb263042d2ba62f1392ed3d4a2
record_format	dspace
spelling	oai:doaj.org-article:063671eb263042d2ba62f1392ed3d4a22021-12-02T14:26:12ZFunctional disability is related to serum chemerin levels in rheumatoid arthritis10.1038/s41598-021-87235-62045-2322https://doaj.org/article/063671eb263042d2ba62f1392ed3d4a22021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87235-6https://doaj.org/toc/2045-2322Abstract Adipokines, especially chemerin, can interact with cytokines and other molecules in inflammation. To date, there is insufficient information regarding a possible correlation between functional disability and chemerin and other pro-inflammatory molecules in rheumatoid arthritis (RA). To identify the association of functional disability with serum chemerin and other pro-inflammatory molecules, including other adipokines, cytokines and E-selectin, in patients with RA. Cross-sectional study. Assessment: disease activity (DAS28-ESR) and functional disability (HAQ-DI). We compared the adipokines (chemerin, leptin, adiponectin, resistin, and visfatin), cytokines (TNF-α, IL-6, IL-1β, and IL-18) and E-selectin levels between RA with functional disability and RA non-disabled patients. Of 82 patients with RA, 43 (52%) had functional disability. The RA with functional disability group had higher chemerin (140 vs. 112 ng/mL, p = 0.007) than the non-disabled RA group. Chemerin correlated with the HAQ-DI (rho = 0.27, p = 0.02) and DAS28-ESR (rho = 0.21, p = 0.05). Severe activity correlated with IL-6 (rho = 0.33, p = 0.003) and E-selectin (rho = 0.23, p = 0.03) but not with disability. No other pro-inflammatory molecules correlated with HAQ-DI. High chemerin levels were associated with functional disability in RA, whereas no other molecules correlated with loss of function. These results encourage further studies assessing new roles of chemerin as a marker of impairment in RA.Maria Luisa Vazquez-VillegasJorge I. Gamez-NavaA. Miriam Saldaña-CruzAlfredo CelisEsther N. Sanchez-RodriguezEdsaul Emilio Perez-GuerreroMelissa Ramirez-VillafañaCesar Arturo Nava-ValdiviaBetsabe Contreras-HaroJose C. Vasquez-JimenezJuan M. Ponce-GuarnerosAna K. Barocio-RamirezSergio Cerpa-CruzMiriam F. Alcaraz-LopezLaura Gonzalez-LopezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Luisa Vazquez-Villegas Jorge I. Gamez-Nava A. Miriam Saldaña-Cruz Alfredo Celis Esther N. Sanchez-Rodriguez Edsaul Emilio Perez-Guerrero Melissa Ramirez-Villafaña Cesar Arturo Nava-Valdivia Betsabe Contreras-Haro Jose C. Vasquez-Jimenez Juan M. Ponce-Guarneros Ana K. Barocio-Ramirez Sergio Cerpa-Cruz Miriam F. Alcaraz-Lopez Laura Gonzalez-Lopez Functional disability is related to serum chemerin levels in rheumatoid arthritis
description	Abstract Adipokines, especially chemerin, can interact with cytokines and other molecules in inflammation. To date, there is insufficient information regarding a possible correlation between functional disability and chemerin and other pro-inflammatory molecules in rheumatoid arthritis (RA). To identify the association of functional disability with serum chemerin and other pro-inflammatory molecules, including other adipokines, cytokines and E-selectin, in patients with RA. Cross-sectional study. Assessment: disease activity (DAS28-ESR) and functional disability (HAQ-DI). We compared the adipokines (chemerin, leptin, adiponectin, resistin, and visfatin), cytokines (TNF-α, IL-6, IL-1β, and IL-18) and E-selectin levels between RA with functional disability and RA non-disabled patients. Of 82 patients with RA, 43 (52%) had functional disability. The RA with functional disability group had higher chemerin (140 vs. 112 ng/mL, p = 0.007) than the non-disabled RA group. Chemerin correlated with the HAQ-DI (rho = 0.27, p = 0.02) and DAS28-ESR (rho = 0.21, p = 0.05). Severe activity correlated with IL-6 (rho = 0.33, p = 0.003) and E-selectin (rho = 0.23, p = 0.03) but not with disability. No other pro-inflammatory molecules correlated with HAQ-DI. High chemerin levels were associated with functional disability in RA, whereas no other molecules correlated with loss of function. These results encourage further studies assessing new roles of chemerin as a marker of impairment in RA.
format	article
author	Maria Luisa Vazquez-Villegas Jorge I. Gamez-Nava A. Miriam Saldaña-Cruz Alfredo Celis Esther N. Sanchez-Rodriguez Edsaul Emilio Perez-Guerrero Melissa Ramirez-Villafaña Cesar Arturo Nava-Valdivia Betsabe Contreras-Haro Jose C. Vasquez-Jimenez Juan M. Ponce-Guarneros Ana K. Barocio-Ramirez Sergio Cerpa-Cruz Miriam F. Alcaraz-Lopez Laura Gonzalez-Lopez
author_facet	Maria Luisa Vazquez-Villegas Jorge I. Gamez-Nava A. Miriam Saldaña-Cruz Alfredo Celis Esther N. Sanchez-Rodriguez Edsaul Emilio Perez-Guerrero Melissa Ramirez-Villafaña Cesar Arturo Nava-Valdivia Betsabe Contreras-Haro Jose C. Vasquez-Jimenez Juan M. Ponce-Guarneros Ana K. Barocio-Ramirez Sergio Cerpa-Cruz Miriam F. Alcaraz-Lopez Laura Gonzalez-Lopez
author_sort	Maria Luisa Vazquez-Villegas
title	Functional disability is related to serum chemerin levels in rheumatoid arthritis
title_short	Functional disability is related to serum chemerin levels in rheumatoid arthritis
title_full	Functional disability is related to serum chemerin levels in rheumatoid arthritis
title_fullStr	Functional disability is related to serum chemerin levels in rheumatoid arthritis
title_full_unstemmed	Functional disability is related to serum chemerin levels in rheumatoid arthritis
title_sort	functional disability is related to serum chemerin levels in rheumatoid arthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/063671eb263042d2ba62f1392ed3d4a2
work_keys_str_mv	AT marialuisavazquezvillegas functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT jorgeigameznava functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT amiriamsaldanacruz functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT alfredocelis functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT esthernsanchezrodriguez functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT edsaulemilioperezguerrero functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT melissaramirezvillafana functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT cesararturonavavaldivia functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT betsabecontrerasharo functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT josecvasquezjimenez functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT juanmponceguarneros functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT anakbarocioramirez functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT sergiocerpacruz functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT miriamfalcarazlopez functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis AT lauragonzalezlopez functionaldisabilityisrelatedtoserumchemerinlevelsinrheumatoidarthritis
_version_	1718391350107308032

Functional disability is related to serum chemerin levels in rheumatoid arthritis

Ejemplares similares