Comparing the controlled attenuation parameter using FibroScan and attenuation imaging with ultrasound as a novel measurement for liver steatosis.

<h4>Background/aims</h4>In a recent study, attenuation imaging (ATI) with ultrasound was used as a new approach for detecting liver steatosis. However, although there are many studies on ATI and controlled attenuation parameter (CAP) that prove their practicability, there are few studies...

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Autores principales:	Po-Ke Hsu, Li-Sha Wu, Wei-Wen Su, Pei-Yuan Su, Yang-Yuan Chen, Yu-Chun Hsu, Hsu-Heng Yen, Chia-Lin Wu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0639cd18204a473998ee5e8335dcb11e
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spelling	oai:doaj.org-article:0639cd18204a473998ee5e8335dcb11e2021-12-02T20:13:41ZComparing the controlled attenuation parameter using FibroScan and attenuation imaging with ultrasound as a novel measurement for liver steatosis.1932-620310.1371/journal.pone.0254892https://doaj.org/article/0639cd18204a473998ee5e8335dcb11e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254892https://doaj.org/toc/1932-6203<h4>Background/aims</h4>In a recent study, attenuation imaging (ATI) with ultrasound was used as a new approach for detecting liver steatosis. However, although there are many studies on ATI and controlled attenuation parameter (CAP) that prove their practicability, there are few studies comparing these two methods. As such, this study compared CAP and ATI for the detection and evaluation of liver steatosis.<h4>Methods</h4>A prospective analysis of 28 chronic liver disease patients who underwent liver biopsy, FibroScan® imaging, and ATI with ultrasound was conducted. The presence and degree of steatosis, as measured with the FibroScan® device and ATI, were compared with the pathological results obtained using liver biopsy.<h4>Results</h4>The areas under the receiver operating characteristic curve (AUROC) of ATI and CAP for differentiating between normal and hepatic steatosis were 0.97 (95% confidence interval [CI] 0.83-1.00) and 0.96 (95% CI 0.81-0.99), respectively. ATI has a higher AUROC than CAP does in liver steatosis, at 0.99 (95% CI, 0.86-1.00) versus 0.91 (95% CI, 0.74-0.98) in grade ≥ 2 and 0.97 (95% CI, 0.82-1.00) versus 0.88 (95% CI, 0.70-0.97) in grade = 3, respectively.<h4>Conclusion</h4>The ATI and CAP results showed good consistency and accuracy for the steatosis grading when compared with the liver biopsy results. Moreover, ATI is even better than CAP in patients with moderate or severe steatosis. Therefore, ATI represents a non-invasive and novel diagnostic tool with which to support the diagnosis of liver steatosis in clinical practice.Po-Ke HsuLi-Sha WuWei-Wen SuPei-Yuan SuYang-Yuan ChenYu-Chun HsuHsu-Heng YenChia-Lin WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0254892 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Po-Ke Hsu Li-Sha Wu Wei-Wen Su Pei-Yuan Su Yang-Yuan Chen Yu-Chun Hsu Hsu-Heng Yen Chia-Lin Wu Comparing the controlled attenuation parameter using FibroScan and attenuation imaging with ultrasound as a novel measurement for liver steatosis.
description	<h4>Background/aims</h4>In a recent study, attenuation imaging (ATI) with ultrasound was used as a new approach for detecting liver steatosis. However, although there are many studies on ATI and controlled attenuation parameter (CAP) that prove their practicability, there are few studies comparing these two methods. As such, this study compared CAP and ATI for the detection and evaluation of liver steatosis.<h4>Methods</h4>A prospective analysis of 28 chronic liver disease patients who underwent liver biopsy, FibroScan® imaging, and ATI with ultrasound was conducted. The presence and degree of steatosis, as measured with the FibroScan® device and ATI, were compared with the pathological results obtained using liver biopsy.<h4>Results</h4>The areas under the receiver operating characteristic curve (AUROC) of ATI and CAP for differentiating between normal and hepatic steatosis were 0.97 (95% confidence interval [CI] 0.83-1.00) and 0.96 (95% CI 0.81-0.99), respectively. ATI has a higher AUROC than CAP does in liver steatosis, at 0.99 (95% CI, 0.86-1.00) versus 0.91 (95% CI, 0.74-0.98) in grade ≥ 2 and 0.97 (95% CI, 0.82-1.00) versus 0.88 (95% CI, 0.70-0.97) in grade = 3, respectively.<h4>Conclusion</h4>The ATI and CAP results showed good consistency and accuracy for the steatosis grading when compared with the liver biopsy results. Moreover, ATI is even better than CAP in patients with moderate or severe steatosis. Therefore, ATI represents a non-invasive and novel diagnostic tool with which to support the diagnosis of liver steatosis in clinical practice.
format	article
author	Po-Ke Hsu Li-Sha Wu Wei-Wen Su Pei-Yuan Su Yang-Yuan Chen Yu-Chun Hsu Hsu-Heng Yen Chia-Lin Wu
author_facet	Po-Ke Hsu Li-Sha Wu Wei-Wen Su Pei-Yuan Su Yang-Yuan Chen Yu-Chun Hsu Hsu-Heng Yen Chia-Lin Wu
author_sort	Po-Ke Hsu
title	Comparing the controlled attenuation parameter using FibroScan and attenuation imaging with ultrasound as a novel measurement for liver steatosis.
title_short	Comparing the controlled attenuation parameter using FibroScan and attenuation imaging with ultrasound as a novel measurement for liver steatosis.
title_full	Comparing the controlled attenuation parameter using FibroScan and attenuation imaging with ultrasound as a novel measurement for liver steatosis.
title_fullStr	Comparing the controlled attenuation parameter using FibroScan and attenuation imaging with ultrasound as a novel measurement for liver steatosis.
title_full_unstemmed	Comparing the controlled attenuation parameter using FibroScan and attenuation imaging with ultrasound as a novel measurement for liver steatosis.
title_sort	comparing the controlled attenuation parameter using fibroscan and attenuation imaging with ultrasound as a novel measurement for liver steatosis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0639cd18204a473998ee5e8335dcb11e
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Comparing the controlled attenuation parameter using FibroScan and attenuation imaging with ultrasound as a novel measurement for liver steatosis.

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