Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance

Yolk sac tumours are a type of ovarian germ cell tumours. Here, the authors perform exome and RNA sequencing of clinical samples of 30 patients, characterize the mutational landscape of these rare tumours, and identify molecular features associated with resistance to cisplatin-based therapies.

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Autores principales:	Xuan Zong, Ying Zhang, Xinxin Peng, Dongyan Cao, Mei Yu, Jinhui Wang, Hongyue Li, Xuejiao Guo, Han Liang, Jiaxin Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/063d5a2ce1914f57be9ca56c3f636a4d
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spelling	oai:doaj.org-article:063d5a2ce1914f57be9ca56c3f636a4d2021-12-02T17:52:24ZAnalysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance10.1038/s41467-021-23681-02041-1723https://doaj.org/article/063d5a2ce1914f57be9ca56c3f636a4d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23681-0https://doaj.org/toc/2041-1723Yolk sac tumours are a type of ovarian germ cell tumours. Here, the authors perform exome and RNA sequencing of clinical samples of 30 patients, characterize the mutational landscape of these rare tumours, and identify molecular features associated with resistance to cisplatin-based therapies.Xuan ZongYing ZhangXinxin PengDongyan CaoMei YuJinhui WangHongyue LiXuejiao GuoHan LiangJiaxin YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuan Zong Ying Zhang Xinxin Peng Dongyan Cao Mei Yu Jinhui Wang Hongyue Li Xuejiao Guo Han Liang Jiaxin Yang Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance
description	Yolk sac tumours are a type of ovarian germ cell tumours. Here, the authors perform exome and RNA sequencing of clinical samples of 30 patients, characterize the mutational landscape of these rare tumours, and identify molecular features associated with resistance to cisplatin-based therapies.
format	article
author	Xuan Zong Ying Zhang Xinxin Peng Dongyan Cao Mei Yu Jinhui Wang Hongyue Li Xuejiao Guo Han Liang Jiaxin Yang
author_facet	Xuan Zong Ying Zhang Xinxin Peng Dongyan Cao Mei Yu Jinhui Wang Hongyue Li Xuejiao Guo Han Liang Jiaxin Yang
author_sort	Xuan Zong
title	Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance
title_short	Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance
title_full	Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance
title_fullStr	Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance
title_full_unstemmed	Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance
title_sort	analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/063d5a2ce1914f57be9ca56c3f636a4d
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Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance

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