Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study
Abstract Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Here we test causality of SMOX levels wi...
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Nature Portfolio
2021
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oai:doaj.org-article:064053270d5b471ba5be3613d0db5c342021-12-02T19:04:19ZGenetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study10.1038/s41598-021-97069-x2045-2322https://doaj.org/article/064053270d5b471ba5be3613d0db5c342021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97069-xhttps://doaj.org/toc/2045-2322Abstract Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Here we test causality of SMOX levels with cancer risk using a Mendelian randomization analysis. We performed a GWAS of spermidine/spermine ratio to identify genetic variants associated with regulation of SMOX activity. Replication analysis was performed in two datasets of SMOX gene expression. We then did a Mendelian randomization analysis by testing the association between the SMOX genetic instrument and neuroblastoma, gastric, lung, breast, prostate, and colorectal cancers using GWAS summary statistics. GWAS of spermidine/spermine ratio identified SMOX locus (P = 1.34 × 10–49) explaining 32% of the variance. The lead SNP rs1741315 was also associated with SMOX gene expression in newborns (P = 8.48 × 10–28) and adults (P = 2.748 × 10–8) explaining 37% and 6% of the variance, respectively. Genetically determined SMOX activity was not associated with neuroblastoma, gastric, lung, breast, prostate nor colorectal cancer (P > 0.05). A PheWAS of rs1741315 did not reveal any relevant associations. Common genetic variation in the SMOX gene was strongly associated with SMOX activity in newborns, and less strongly in adults. Genetic down-regulation of SMOX was not significantly associated with lower odds of neuroblastoma, gastric, lung, breast, prostate and colorectal cancer. These results may inform studies of SMOX inhibition as a target for chemoprevention.João FadistaVictor YakimovUrmo VõsaChristine S. HansenSilva KaselaLine SkotteFrank GellerJulie CourraudTõnu EskoViktorija KukuškinaAlfonso BuilMads MelbyeThomas M. WergeDavid M. HougaardLili MilaniJonas Bybjerg-GrauholmArieh S. CohenBjarke FeenstraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q João Fadista Victor Yakimov Urmo Võsa Christine S. Hansen Silva Kasela Line Skotte Frank Geller Julie Courraud Tõnu Esko Viktorija Kukuškina Alfonso Buil Mads Melbye Thomas M. Werge David M. Hougaard Lili Milani Jonas Bybjerg-Grauholm Arieh S. Cohen Bjarke Feenstra Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study |
| description |
Abstract Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Here we test causality of SMOX levels with cancer risk using a Mendelian randomization analysis. We performed a GWAS of spermidine/spermine ratio to identify genetic variants associated with regulation of SMOX activity. Replication analysis was performed in two datasets of SMOX gene expression. We then did a Mendelian randomization analysis by testing the association between the SMOX genetic instrument and neuroblastoma, gastric, lung, breast, prostate, and colorectal cancers using GWAS summary statistics. GWAS of spermidine/spermine ratio identified SMOX locus (P = 1.34 × 10–49) explaining 32% of the variance. The lead SNP rs1741315 was also associated with SMOX gene expression in newborns (P = 8.48 × 10–28) and adults (P = 2.748 × 10–8) explaining 37% and 6% of the variance, respectively. Genetically determined SMOX activity was not associated with neuroblastoma, gastric, lung, breast, prostate nor colorectal cancer (P > 0.05). A PheWAS of rs1741315 did not reveal any relevant associations. Common genetic variation in the SMOX gene was strongly associated with SMOX activity in newborns, and less strongly in adults. Genetic down-regulation of SMOX was not significantly associated with lower odds of neuroblastoma, gastric, lung, breast, prostate and colorectal cancer. These results may inform studies of SMOX inhibition as a target for chemoprevention. |
| format |
article |
| author |
João Fadista Victor Yakimov Urmo Võsa Christine S. Hansen Silva Kasela Line Skotte Frank Geller Julie Courraud Tõnu Esko Viktorija Kukuškina Alfonso Buil Mads Melbye Thomas M. Werge David M. Hougaard Lili Milani Jonas Bybjerg-Grauholm Arieh S. Cohen Bjarke Feenstra |
| author_facet |
João Fadista Victor Yakimov Urmo Võsa Christine S. Hansen Silva Kasela Line Skotte Frank Geller Julie Courraud Tõnu Esko Viktorija Kukuškina Alfonso Buil Mads Melbye Thomas M. Werge David M. Hougaard Lili Milani Jonas Bybjerg-Grauholm Arieh S. Cohen Bjarke Feenstra |
| author_sort |
João Fadista |
| title |
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study |
| title_short |
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study |
| title_full |
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study |
| title_fullStr |
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study |
| title_full_unstemmed |
Genetic regulation of spermine oxidase activity and cancer risk: a Mendelian randomization study |
| title_sort |
genetic regulation of spermine oxidase activity and cancer risk: a mendelian randomization study |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/064053270d5b471ba5be3613d0db5c34 |
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