Retinal organoids as models for development and diseases

Abstract The evolution of pluripotent stem cell-derived retinal organoids (ROs) has brought remarkable opportunities for developmental studies while also presenting new therapeutic avenues for retinal diseases. With a clear understanding of how well these models mimic native retinas, such preclinica...

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Autores principales:	Xiao Zhang, Wen Wang, Zi-Bing Jin
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0640584c7501407fb61cb62ea0410789
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spelling	oai:doaj.org-article:0640584c7501407fb61cb62ea04107892021-11-14T12:39:16ZRetinal organoids as models for development and diseases10.1186/s13619-021-00097-12045-9769https://doaj.org/article/0640584c7501407fb61cb62ea04107892021-11-01T00:00:00Zhttps://doi.org/10.1186/s13619-021-00097-1https://doaj.org/toc/2045-9769Abstract The evolution of pluripotent stem cell-derived retinal organoids (ROs) has brought remarkable opportunities for developmental studies while also presenting new therapeutic avenues for retinal diseases. With a clear understanding of how well these models mimic native retinas, such preclinical models may be crucial tools that are widely used for the more efficient translation of studies into novel treatment strategies for retinal diseases. Genetic modifications or patient-derived ROs can allow these models to simulate the physical microenvironments of the actual disease process. However, we are currently at the beginning of the three-dimensional (3D) RO era, and a general quantitative technology for analyzing ROs derived from numerous differentiation protocols is still missing. Continued efforts to improve the efficiency and stability of differentiation, as well as understanding the disparity between the artificial retina and the native retina and advancing the current treatment strategies, will be essential in ensuring that these scientific advances can benefit patients with retinal disease. Herein, we briefly discuss RO differentiation protocols, the current applications of RO as a disease model and the treatments for retinal diseases by using RO modeling, to have a clear view of the role of current ROs in retinal development and diseases.Xiao ZhangWen WangZi-Bing JinSpringerOpenarticleMedicine (General)R5-920Biology (General)QH301-705.5ENCell Regeneration, Vol 10, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	Medicine (General) R5-920 Biology (General) QH301-705.5 Xiao Zhang Wen Wang Zi-Bing Jin Retinal organoids as models for development and diseases
description	Abstract The evolution of pluripotent stem cell-derived retinal organoids (ROs) has brought remarkable opportunities for developmental studies while also presenting new therapeutic avenues for retinal diseases. With a clear understanding of how well these models mimic native retinas, such preclinical models may be crucial tools that are widely used for the more efficient translation of studies into novel treatment strategies for retinal diseases. Genetic modifications or patient-derived ROs can allow these models to simulate the physical microenvironments of the actual disease process. However, we are currently at the beginning of the three-dimensional (3D) RO era, and a general quantitative technology for analyzing ROs derived from numerous differentiation protocols is still missing. Continued efforts to improve the efficiency and stability of differentiation, as well as understanding the disparity between the artificial retina and the native retina and advancing the current treatment strategies, will be essential in ensuring that these scientific advances can benefit patients with retinal disease. Herein, we briefly discuss RO differentiation protocols, the current applications of RO as a disease model and the treatments for retinal diseases by using RO modeling, to have a clear view of the role of current ROs in retinal development and diseases.
format	article
author	Xiao Zhang Wen Wang Zi-Bing Jin
author_facet	Xiao Zhang Wen Wang Zi-Bing Jin
author_sort	Xiao Zhang
title	Retinal organoids as models for development and diseases
title_short	Retinal organoids as models for development and diseases
title_full	Retinal organoids as models for development and diseases
title_fullStr	Retinal organoids as models for development and diseases
title_full_unstemmed	Retinal organoids as models for development and diseases
title_sort	retinal organoids as models for development and diseases
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/0640584c7501407fb61cb62ea0410789
work_keys_str_mv	AT xiaozhang retinalorganoidsasmodelsfordevelopmentanddiseases AT wenwang retinalorganoidsasmodelsfordevelopmentanddiseases AT zibingjin retinalorganoidsasmodelsfordevelopmentanddiseases
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Retinal organoids as models for development and diseases

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