Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries

Abstract In-stent restenosis (ISR) is the major drawback of superficial femoral artery (SFA) stenting. Abnormal hemodynamics after stent implantation seems to promote the development of ISR. Accordingly, this study aims to investigate the impact of local hemodynamics on lumen remodeling in human ste...

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Autores principales:	Monika Colombo, Yong He, Anna Corti, Diego Gallo, Stefano Casarin, Jared M. Rozowsky, Francesco Migliavacca, Scott Berceli, Claudio Chiastra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0643bc654b8b43e29e6eee3efbe0dc06
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spelling	oai:doaj.org-article:0643bc654b8b43e29e6eee3efbe0dc062021-12-02T14:01:24ZBaseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries10.1038/s41598-020-80681-82045-2322https://doaj.org/article/0643bc654b8b43e29e6eee3efbe0dc062021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80681-8https://doaj.org/toc/2045-2322Abstract In-stent restenosis (ISR) is the major drawback of superficial femoral artery (SFA) stenting. Abnormal hemodynamics after stent implantation seems to promote the development of ISR. Accordingly, this study aims to investigate the impact of local hemodynamics on lumen remodeling in human stented SFA lesions. Ten SFA models were reconstructed at 1-week and 1-year follow-up from computed tomography images. Patient-specific computational fluid dynamics simulations were performed to relate the local hemodynamics at 1-week, expressed in terms of time-averaged wall shear stress (TAWSS), oscillatory shear index and relative residence time, with the lumen remodeling at 1-year, quantified as the change of lumen area between 1-week and 1-year. The TAWSS was negatively associated with the lumen area change (ρ = − 0.75, p = 0.013). The surface area exposed to low TAWSS was positively correlated with the lumen area change (ρ = 0.69, p = 0.026). No significant correlations were present between the other hemodynamic descriptors and lumen area change. The low TAWSS was the best predictive marker of lumen remodeling (positive predictive value of 44.8%). Moreover, stent length and overlapping were predictor of ISR at follow-up. Despite the limited number of analyzed lesions, the overall findings suggest an association between abnormal patterns of WSS after stenting and lumen remodeling.Monika ColomboYong HeAnna CortiDiego GalloStefano CasarinJared M. RozowskyFrancesco MigliavaccaScott BerceliClaudio ChiastraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Monika Colombo Yong He Anna Corti Diego Gallo Stefano Casarin Jared M. Rozowsky Francesco Migliavacca Scott Berceli Claudio Chiastra Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries
description	Abstract In-stent restenosis (ISR) is the major drawback of superficial femoral artery (SFA) stenting. Abnormal hemodynamics after stent implantation seems to promote the development of ISR. Accordingly, this study aims to investigate the impact of local hemodynamics on lumen remodeling in human stented SFA lesions. Ten SFA models were reconstructed at 1-week and 1-year follow-up from computed tomography images. Patient-specific computational fluid dynamics simulations were performed to relate the local hemodynamics at 1-week, expressed in terms of time-averaged wall shear stress (TAWSS), oscillatory shear index and relative residence time, with the lumen remodeling at 1-year, quantified as the change of lumen area between 1-week and 1-year. The TAWSS was negatively associated with the lumen area change (ρ = − 0.75, p = 0.013). The surface area exposed to low TAWSS was positively correlated with the lumen area change (ρ = 0.69, p = 0.026). No significant correlations were present between the other hemodynamic descriptors and lumen area change. The low TAWSS was the best predictive marker of lumen remodeling (positive predictive value of 44.8%). Moreover, stent length and overlapping were predictor of ISR at follow-up. Despite the limited number of analyzed lesions, the overall findings suggest an association between abnormal patterns of WSS after stenting and lumen remodeling.
format	article
author	Monika Colombo Yong He Anna Corti Diego Gallo Stefano Casarin Jared M. Rozowsky Francesco Migliavacca Scott Berceli Claudio Chiastra
author_facet	Monika Colombo Yong He Anna Corti Diego Gallo Stefano Casarin Jared M. Rozowsky Francesco Migliavacca Scott Berceli Claudio Chiastra
author_sort	Monika Colombo
title	Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries
title_short	Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries
title_full	Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries
title_fullStr	Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries
title_full_unstemmed	Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries
title_sort	baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0643bc654b8b43e29e6eee3efbe0dc06
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Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries

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