Previous antiretroviral drug use compromises standard first-line HIV therapy and is mediated through drug-resistance

Previous antiretroviral drug use compromises standard first-line HIV therapy and is mediated through drug-resistance

Abstract In ART programs in sub-Saharan Africa, a growing proportion of HIV-infected persons initiating first-line antiretroviral therapy (ART) have a history of prior antiretroviral drug use (PAU). We assessed the effect of PAU on the risk of pre-treatment drug resistance (PDR) and virological fail...

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Autores principales: Seth C. Inzaule, Cissy M. Kityo, Margaret Siwale, Alani Sulaimon Akanmu, Maureen Wellington, Marleen de Jager, Prudence Ive, Kishor Mandaliya, Wendy Stevens, T. Sonia Boender, Pascale Ondoa, Kim C. E. Sigaloff, Denise Naniche, Tobias F. Rinke de Wit, Raph L. Hamers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Causal Mediation Analysis
First-line Empirical Therapy
Non-nucleoside Reverse Transcriptase Inhibitors (NNRTI)
Virological Failure (VF)
Prevention Of Mother-to-child Transmission (PMTCT)
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0647a6dbb601463f9750fafd510d38ea
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