Impact of varicella vaccine on nosocomial outbreaks and management of post exposure prophylaxis following in a paediatric hospital.

<h4>Introduction</h4>In 2015, varicella vaccine was introduced to the National Immunization Programme in a one-dose regimen for infants aged 15 months. The aim of this study was to describe and compare the epidemiologic characteristics, management strategies and costs of varicella outbre...

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Autores principales:	Angela Gentile, Norberto Giglio, Maria Florencia Lucion, Ana Clara Martínez, Natalia Pejito, Maria Del Valle Juarez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0647a92d4497409e879729809335a9e3
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spelling	oai:doaj.org-article:0647a92d4497409e879729809335a9e32021-11-25T06:23:45ZImpact of varicella vaccine on nosocomial outbreaks and management of post exposure prophylaxis following in a paediatric hospital.1932-620310.1371/journal.pone.0251496https://doaj.org/article/0647a92d4497409e879729809335a9e32021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251496https://doaj.org/toc/1932-6203<h4>Introduction</h4>In 2015, varicella vaccine was introduced to the National Immunization Programme in a one-dose regimen for infants aged 15 months. The aim of this study was to describe and compare the epidemiologic characteristics, management strategies and costs of varicella outbreaks in Ricardo Gutierrez Children's Hospital (HNRG) from 2000 to 2019, before (PreV period) and after (PostV period) the introduction of the varicella vaccine.<h4>Methods</h4>A retrospective, analytic study of the impact of nosocomial varicella outbreaks at the HNRG, based on active epidemiologic surveillance. We compared nosocomial varicella outbreaks rates (per 10,000 discharges) between PreV and PostV, excluding the intervention year (2015).<h4>Results</h4>During PreV, an average of 15.87 (13.91-18.02) outbreaks per year was observed and in PostV 5.5 per year (3.44-8.32). Outbreaks adjusted by all cause discharges showed a reduction of 59.13% (-36.68%, -73.62%) after vaccine introduction. Considering that in PreV the average of susceptible cases per outbreak was 5.0 and in PostV 7.8, with a cost per susceptible of AR$ $6,522 (80.27 USD) PreV and 6,708 PostV the economic impact on the reduction of outbreaks after the introduction of the vaccine, showed an estimated average savings per year of AR$ -252,128 AR$ (-3,103.11 USD).<h4>Conclusions</h4>The number of annual varicella hospital outbreaks at the HNRG decreased significantly after varicella vaccine was introduced to NIP in Argentina with a relevant reduction in terms of costs.Angela GentileNorberto GiglioMaria Florencia LucionAna Clara MartínezNatalia PejitoMaria Del Valle JuarezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251496 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angela Gentile Norberto Giglio Maria Florencia Lucion Ana Clara Martínez Natalia Pejito Maria Del Valle Juarez Impact of varicella vaccine on nosocomial outbreaks and management of post exposure prophylaxis following in a paediatric hospital.
description	<h4>Introduction</h4>In 2015, varicella vaccine was introduced to the National Immunization Programme in a one-dose regimen for infants aged 15 months. The aim of this study was to describe and compare the epidemiologic characteristics, management strategies and costs of varicella outbreaks in Ricardo Gutierrez Children's Hospital (HNRG) from 2000 to 2019, before (PreV period) and after (PostV period) the introduction of the varicella vaccine.<h4>Methods</h4>A retrospective, analytic study of the impact of nosocomial varicella outbreaks at the HNRG, based on active epidemiologic surveillance. We compared nosocomial varicella outbreaks rates (per 10,000 discharges) between PreV and PostV, excluding the intervention year (2015).<h4>Results</h4>During PreV, an average of 15.87 (13.91-18.02) outbreaks per year was observed and in PostV 5.5 per year (3.44-8.32). Outbreaks adjusted by all cause discharges showed a reduction of 59.13% (-36.68%, -73.62%) after vaccine introduction. Considering that in PreV the average of susceptible cases per outbreak was 5.0 and in PostV 7.8, with a cost per susceptible of AR$ $6,522 (80.27 USD) PreV and 6,708 PostV the economic impact on the reduction of outbreaks after the introduction of the vaccine, showed an estimated average savings per year of AR$ -252,128 AR$ (-3,103.11 USD).<h4>Conclusions</h4>The number of annual varicella hospital outbreaks at the HNRG decreased significantly after varicella vaccine was introduced to NIP in Argentina with a relevant reduction in terms of costs.
format	article
author	Angela Gentile Norberto Giglio Maria Florencia Lucion Ana Clara Martínez Natalia Pejito Maria Del Valle Juarez
author_facet	Angela Gentile Norberto Giglio Maria Florencia Lucion Ana Clara Martínez Natalia Pejito Maria Del Valle Juarez
author_sort	Angela Gentile
title	Impact of varicella vaccine on nosocomial outbreaks and management of post exposure prophylaxis following in a paediatric hospital.
title_short	Impact of varicella vaccine on nosocomial outbreaks and management of post exposure prophylaxis following in a paediatric hospital.
title_full	Impact of varicella vaccine on nosocomial outbreaks and management of post exposure prophylaxis following in a paediatric hospital.
title_fullStr	Impact of varicella vaccine on nosocomial outbreaks and management of post exposure prophylaxis following in a paediatric hospital.
title_full_unstemmed	Impact of varicella vaccine on nosocomial outbreaks and management of post exposure prophylaxis following in a paediatric hospital.
title_sort	impact of varicella vaccine on nosocomial outbreaks and management of post exposure prophylaxis following in a paediatric hospital.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0647a92d4497409e879729809335a9e3
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Impact of varicella vaccine on nosocomial outbreaks and management of post exposure prophylaxis following in a paediatric hospital.

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