Three cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip

Masahisa Arahata,1 Shigeru Shimadoi,1 Satosi Yamatani,1 Shin-ichi Hayashi,2 Shigeharu Miwa,2 Hidesaku Asakura,3 Shinji Nakao4 1Department of Internal Medicine, Nanto Municipal Hospital, Nanto, 2Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Arahata M, Shimadoi S, Yamatani S, Hayashi S, Miwa S, Asakura H, Nakao S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	systemic amyloidosis amyloid cardiomyopathy fine-needle aspiration biopsy subcutaneous fat tissue hip abdominal fat pad Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/064a65b010a241c1aa74e2c94af936a8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:064a65b010a241c1aa74e2c94af936a8
record_format	dspace
spelling	oai:doaj.org-article:064a65b010a241c1aa74e2c94af936a82021-12-02T00:33:30ZThree cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip1178-1998https://doaj.org/article/064a65b010a241c1aa74e2c94af936a82016-08-01T00:00:00Zhttps://www.dovepress.com/three-cases-of-systemic-amyloidosis-successfully-diagnosed-by-subcutan-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Masahisa Arahata,1 Shigeru Shimadoi,1 Satosi Yamatani,1 Shin-ichi Hayashi,2 Shigeharu Miwa,2 Hidesaku Asakura,3 Shinji Nakao4 1Department of Internal Medicine, Nanto Municipal Hospital, Nanto, 2Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 3Department of Internal Medicine (III), 4Department of Cellular Transplantation Biology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan Abstract: Fine-needle aspiration biopsy of the abdominal fat pad is considered to be a minimally invasive procedure for diagnosing systemic amyloidosis. However, this procedure is sometimes difficult and can be dangerous for elderly patients whose abdominal fat layer is thin because of malnutrition. In such cases, alternative diagnostic methods are required. We report three elderly patients with heart failure complicated by malnutrition. In all cases, electrocardiogram showed low voltage in the limb leads and a pseudoinfarct pattern in the chest leads, and echocardiography showed left ventricular wall thickening with granular sparkling appearance. These patients were suspected of having amyloid cardiomyopathy but could not undergo myocardial biopsies because of their poor conditions. After failed attempts at biopsy of the abdominal fat pad or the other organs, subcutaneous fat tissue biopsy over the hip led to the diagnosis of systemic amyloidosis with cardiomyopathy. The resultant diagnosis guided us to choose the appropriate treatment for the patients. This article illustrates that subcutaneous fat tissue biopsy of the hip could be a useful procedure for diagnosing systemic amyloidosis in elderly patients, particularly when a fat tissue biopsy of the abdomen is associated with a high risk of complications because of malnutrition. Keywords: systemic amyloidosis, amyloid cardiomyopathy, fine-needle aspiration biopsy, subcutaneous fat tissue, hip, abdominal fat padArahata MShimadoi SYamatani SHayashi SMiwa SAsakura HNakao SDove Medical Pressarticlesystemic amyloidosisamyloid cardiomyopathyfine-needle aspiration biopsysubcutaneous fat tissuehipabdominal fat padGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 1061-1066 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	systemic amyloidosis amyloid cardiomyopathy fine-needle aspiration biopsy subcutaneous fat tissue hip abdominal fat pad Geriatrics RC952-954.6
spellingShingle	systemic amyloidosis amyloid cardiomyopathy fine-needle aspiration biopsy subcutaneous fat tissue hip abdominal fat pad Geriatrics RC952-954.6 Arahata M Shimadoi S Yamatani S Hayashi S Miwa S Asakura H Nakao S Three cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip
description	Masahisa Arahata,1 Shigeru Shimadoi,1 Satosi Yamatani,1 Shin-ichi Hayashi,2 Shigeharu Miwa,2 Hidesaku Asakura,3 Shinji Nakao4 1Department of Internal Medicine, Nanto Municipal Hospital, Nanto, 2Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 3Department of Internal Medicine (III), 4Department of Cellular Transplantation Biology, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan Abstract: Fine-needle aspiration biopsy of the abdominal fat pad is considered to be a minimally invasive procedure for diagnosing systemic amyloidosis. However, this procedure is sometimes difficult and can be dangerous for elderly patients whose abdominal fat layer is thin because of malnutrition. In such cases, alternative diagnostic methods are required. We report three elderly patients with heart failure complicated by malnutrition. In all cases, electrocardiogram showed low voltage in the limb leads and a pseudoinfarct pattern in the chest leads, and echocardiography showed left ventricular wall thickening with granular sparkling appearance. These patients were suspected of having amyloid cardiomyopathy but could not undergo myocardial biopsies because of their poor conditions. After failed attempts at biopsy of the abdominal fat pad or the other organs, subcutaneous fat tissue biopsy over the hip led to the diagnosis of systemic amyloidosis with cardiomyopathy. The resultant diagnosis guided us to choose the appropriate treatment for the patients. This article illustrates that subcutaneous fat tissue biopsy of the hip could be a useful procedure for diagnosing systemic amyloidosis in elderly patients, particularly when a fat tissue biopsy of the abdomen is associated with a high risk of complications because of malnutrition. Keywords: systemic amyloidosis, amyloid cardiomyopathy, fine-needle aspiration biopsy, subcutaneous fat tissue, hip, abdominal fat pad
format	article
author	Arahata M Shimadoi S Yamatani S Hayashi S Miwa S Asakura H Nakao S
author_facet	Arahata M Shimadoi S Yamatani S Hayashi S Miwa S Asakura H Nakao S
author_sort	Arahata M
title	Three cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip
title_short	Three cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip
title_full	Three cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip
title_fullStr	Three cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip
title_full_unstemmed	Three cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip
title_sort	three cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/064a65b010a241c1aa74e2c94af936a8
work_keys_str_mv	AT arahatam threecasesofsystemicamyloidosissuccessfullydiagnosedbysubcutaneousfattissuebiopsyofthehip AT shimadois threecasesofsystemicamyloidosissuccessfullydiagnosedbysubcutaneousfattissuebiopsyofthehip AT yamatanis threecasesofsystemicamyloidosissuccessfullydiagnosedbysubcutaneousfattissuebiopsyofthehip AT hayashis threecasesofsystemicamyloidosissuccessfullydiagnosedbysubcutaneousfattissuebiopsyofthehip AT miwas threecasesofsystemicamyloidosissuccessfullydiagnosedbysubcutaneousfattissuebiopsyofthehip AT asakurah threecasesofsystemicamyloidosissuccessfullydiagnosedbysubcutaneousfattissuebiopsyofthehip AT nakaos threecasesofsystemicamyloidosissuccessfullydiagnosedbysubcutaneousfattissuebiopsyofthehip
_version_	1718403657759719424

Three cases of systemic amyloidosis successfully diagnosed by subcutaneous fat tissue biopsy of the hip

Ejemplares similares