Computer aided designing of novel pyrrolopyridine derivatives as JAK1 inhibitors

Abstract Janus kinases (JAKs) are a family of non-receptor kinases that play a key role in cytokine signaling and their aberrant activities are associated with the pathogenesis of various immune diseases. The JAK1 isoform plays an essential role in the types 1 and II interferon signaling and elicits...

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Autores principales: Seketoulie Keretsu, Suparna Ghosh, Seung Joo Cho
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/064aa1af3b8144639f85b32b9b179cb3
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