To Find Out the Relationship Between Levels of Glycosylated Hemoglobin with Meibomian Gland Dysfunction in Patients with Type 2 Diabetes

Fang Fan,1 Xiaodan Li,2 Kejun Li,1 Zhiyang Jia1 1Department of Ophthalmology, Hebei General Hospital, Shijiazhuang, 050051, People’s Republic of China; 2Department of Ophthalmology, Shijiazhuang People’s Hospital, Shijiazhuang, 050000, People’s Republic of ChinaCorrespondence: Zhiyang JiaDepartment...

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Autores principales:	Fan F, Li X, Li K, Jia Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetes mellitus type 2 diabetes mellitus glycosylated hemoglobin lipid layer thickness percentage of partial glands Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/064bd442346e47329bef5fe13a7623b6
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spelling	oai:doaj.org-article:064bd442346e47329bef5fe13a7623b62021-12-02T14:51:50ZTo Find Out the Relationship Between Levels of Glycosylated Hemoglobin with Meibomian Gland Dysfunction in Patients with Type 2 Diabetes1178-203Xhttps://doaj.org/article/064bd442346e47329bef5fe13a7623b62021-08-01T00:00:00Zhttps://www.dovepress.com/to-find-out-the-relationship-between-levels-of-glycosylated-hemoglobin-peer-reviewed-fulltext-article-TCRMhttps://doaj.org/toc/1178-203XFang Fan,1 Xiaodan Li,2 Kejun Li,1 Zhiyang Jia1 1Department of Ophthalmology, Hebei General Hospital, Shijiazhuang, 050051, People’s Republic of China; 2Department of Ophthalmology, Shijiazhuang People’s Hospital, Shijiazhuang, 050000, People’s Republic of ChinaCorrespondence: Zhiyang JiaDepartment of Ophthalmology, Hebei General Hospital, No. 348 Hepingxi Road, Xinhua District, Shijiazhuang, Hebei, 050051, People’s Republic of ChinaTel +86-13933120759Email jiazhiyangwork88@163.comAim: The aim of this study was to investigate the relationship between levels of glycosylated hemoglobin (HbA1c) with meibomian gland dysfunction (MGD) in patients with type 2 diabetes mellitus (T2DM) and to further explore the related influencing factors.Methods: Totally, 167 patients with T2DM and 68 non-diabetic subjects were selected. Further, T2DM patients were divided into 2 groups based on 7% HbA1c. Standard patient evaluation of eye dryness (SPEED), lipid layer thickness (LLT), partial blink (PB) ratio, percentage of partial glands (MGP), meibomian gland yielding liquid secretion (MGYLS), meibomian gland yielding secretion score (MGYSS), line of marx (LOM), tear break up time (TBUT), tear meniscus height (TMH) and Schirmer I test (SIT) were applied to evaluate meibomian gland function. Finally, the correlation between HbA1c and various indicators was also analyzed.Results: Between HbA1c≥ 7% group and HbA1c< 7% group, the differences in LLT (P=0.003), MGP (P< 0.001), MGYLS (P=0.014) and TBUT (P=0.015) were all statistically significant. Compared with the non-diabetic group, LLT (P=0.020), MBP (P< 0.001), MGYS (P< 0.001), TBUT (P< 0.001), SIT (P=0.001), TMH (P=0.017) and LOM (P< 0.001) were significantly different in HbA1c≥ 7% group, while the differences of MBP (P=0.031), MGYSS (P< 0.001), SIT (P=0.001) and LOM (P< 0.001) in HbA1c≤ 7% group were statistically significant. Besides, the prevalence of MGD in HbA1c≥ 7% group was evidently higher than that in non-diabetic group (P=0.002). Correlation analysis showed that HbA1c was significantly associated with the LTT and MGP.Conclusion: HbA1c≥ 7% is likely to result in meibomian gland function dysfunctions in T2DM patients, especially related to LLT and MGP.Keywords: diabetes mellitus, type 2 diabetes mellitus, glycosylated hemoglobin, lipid layer thickness, percentage of partial glandsFan FLi XLi KJia ZDove Medical Pressarticlediabetes mellitustype 2 diabetes mellitusglycosylated hemoglobinlipid layer thicknesspercentage of partial glandsTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 17, Pp 797-807 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus type 2 diabetes mellitus glycosylated hemoglobin lipid layer thickness percentage of partial glands Therapeutics. Pharmacology RM1-950
spellingShingle	diabetes mellitus type 2 diabetes mellitus glycosylated hemoglobin lipid layer thickness percentage of partial glands Therapeutics. Pharmacology RM1-950 Fan F Li X Li K Jia Z To Find Out the Relationship Between Levels of Glycosylated Hemoglobin with Meibomian Gland Dysfunction in Patients with Type 2 Diabetes
description	Fang Fan,1 Xiaodan Li,2 Kejun Li,1 Zhiyang Jia1 1Department of Ophthalmology, Hebei General Hospital, Shijiazhuang, 050051, People’s Republic of China; 2Department of Ophthalmology, Shijiazhuang People’s Hospital, Shijiazhuang, 050000, People’s Republic of ChinaCorrespondence: Zhiyang JiaDepartment of Ophthalmology, Hebei General Hospital, No. 348 Hepingxi Road, Xinhua District, Shijiazhuang, Hebei, 050051, People’s Republic of ChinaTel +86-13933120759Email jiazhiyangwork88@163.comAim: The aim of this study was to investigate the relationship between levels of glycosylated hemoglobin (HbA1c) with meibomian gland dysfunction (MGD) in patients with type 2 diabetes mellitus (T2DM) and to further explore the related influencing factors.Methods: Totally, 167 patients with T2DM and 68 non-diabetic subjects were selected. Further, T2DM patients were divided into 2 groups based on 7% HbA1c. Standard patient evaluation of eye dryness (SPEED), lipid layer thickness (LLT), partial blink (PB) ratio, percentage of partial glands (MGP), meibomian gland yielding liquid secretion (MGYLS), meibomian gland yielding secretion score (MGYSS), line of marx (LOM), tear break up time (TBUT), tear meniscus height (TMH) and Schirmer I test (SIT) were applied to evaluate meibomian gland function. Finally, the correlation between HbA1c and various indicators was also analyzed.Results: Between HbA1c≥ 7% group and HbA1c< 7% group, the differences in LLT (P=0.003), MGP (P< 0.001), MGYLS (P=0.014) and TBUT (P=0.015) were all statistically significant. Compared with the non-diabetic group, LLT (P=0.020), MBP (P< 0.001), MGYS (P< 0.001), TBUT (P< 0.001), SIT (P=0.001), TMH (P=0.017) and LOM (P< 0.001) were significantly different in HbA1c≥ 7% group, while the differences of MBP (P=0.031), MGYSS (P< 0.001), SIT (P=0.001) and LOM (P< 0.001) in HbA1c≤ 7% group were statistically significant. Besides, the prevalence of MGD in HbA1c≥ 7% group was evidently higher than that in non-diabetic group (P=0.002). Correlation analysis showed that HbA1c was significantly associated with the LTT and MGP.Conclusion: HbA1c≥ 7% is likely to result in meibomian gland function dysfunctions in T2DM patients, especially related to LLT and MGP.Keywords: diabetes mellitus, type 2 diabetes mellitus, glycosylated hemoglobin, lipid layer thickness, percentage of partial glands
format	article
author	Fan F Li X Li K Jia Z
author_facet	Fan F Li X Li K Jia Z
author_sort	Fan F
title	To Find Out the Relationship Between Levels of Glycosylated Hemoglobin with Meibomian Gland Dysfunction in Patients with Type 2 Diabetes
title_short	To Find Out the Relationship Between Levels of Glycosylated Hemoglobin with Meibomian Gland Dysfunction in Patients with Type 2 Diabetes
title_full	To Find Out the Relationship Between Levels of Glycosylated Hemoglobin with Meibomian Gland Dysfunction in Patients with Type 2 Diabetes
title_fullStr	To Find Out the Relationship Between Levels of Glycosylated Hemoglobin with Meibomian Gland Dysfunction in Patients with Type 2 Diabetes
title_full_unstemmed	To Find Out the Relationship Between Levels of Glycosylated Hemoglobin with Meibomian Gland Dysfunction in Patients with Type 2 Diabetes
title_sort	to find out the relationship between levels of glycosylated hemoglobin with meibomian gland dysfunction in patients with type 2 diabetes
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/064bd442346e47329bef5fe13a7623b6
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To Find Out the Relationship Between Levels of Glycosylated Hemoglobin with Meibomian Gland Dysfunction in Patients with Type 2 Diabetes

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