Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults

Depression and related neurobehavioral symptoms are common features of Alzheimer’s disease and other dementias. The presence of these potentially modifiable neurobehavioral symptoms in cognitively intact older adults may represent an early indication of pathophysiological processes in the brain. Tau...

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Autores principales:	James R. Hall, Melissa Petersen, Leigh Johnson, Sid E. O’Bryant
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	plasma tau depression apathy anxiety worry daytime sleepiness Psychology BF1-990
Acceso en línea:	https://doaj.org/article/064c659f826a488fa58ad29d8c2eff75
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spelling	oai:doaj.org-article:064c659f826a488fa58ad29d8c2eff752021-11-05T16:11:12ZPlasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults1664-107810.3389/fpsyg.2021.774049https://doaj.org/article/064c659f826a488fa58ad29d8c2eff752021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyg.2021.774049/fullhttps://doaj.org/toc/1664-1078Depression and related neurobehavioral symptoms are common features of Alzheimer’s disease and other dementias. The presence of these potentially modifiable neurobehavioral symptoms in cognitively intact older adults may represent an early indication of pathophysiological processes in the brain. Tau pathology is a key feature of a number of dementias. A number of studies have found an association between tau and neurobehavioral symptoms. The current study investigated the relationship of a blood-based biomarker of tau and symptoms of depression, anxiety, worry, and sleep disturbances in 538 community based, cognitively normal older adults. Logistic regression revealed no significant relationship between plasma total tau and any measures of neurobehavioral symptoms. To assess the impact of level of tau on these relationships, participants were divided into those in the highest quintile of tau and those in the lower four quintiles. Regression analyses showed a significant relationship between level of plasma total tau and measures of depression, apathy, anxiety, worry and sleep. The presence of higher levels of plasma tau and elevated neurobehavioral symptoms may be an early indicator of cognitive decline and prodromal Alzheimer’s disease. Longitudinal research is needed to evaluate the impact of these factors on the development of dementia and may suggest areas for early intervention.James R. HallJames R. HallMelissa PetersenMelissa PetersenLeigh JohnsonLeigh JohnsonSid E. O’BryantSid E. O’BryantFrontiers Media S.A.articleplasma taudepressionapathyanxietyworrydaytime sleepinessPsychologyBF1-990ENFrontiers in Psychology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	plasma tau depression apathy anxiety worry daytime sleepiness Psychology BF1-990
spellingShingle	plasma tau depression apathy anxiety worry daytime sleepiness Psychology BF1-990 James R. Hall James R. Hall Melissa Petersen Melissa Petersen Leigh Johnson Leigh Johnson Sid E. O’Bryant Sid E. O’Bryant Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults
description	Depression and related neurobehavioral symptoms are common features of Alzheimer’s disease and other dementias. The presence of these potentially modifiable neurobehavioral symptoms in cognitively intact older adults may represent an early indication of pathophysiological processes in the brain. Tau pathology is a key feature of a number of dementias. A number of studies have found an association between tau and neurobehavioral symptoms. The current study investigated the relationship of a blood-based biomarker of tau and symptoms of depression, anxiety, worry, and sleep disturbances in 538 community based, cognitively normal older adults. Logistic regression revealed no significant relationship between plasma total tau and any measures of neurobehavioral symptoms. To assess the impact of level of tau on these relationships, participants were divided into those in the highest quintile of tau and those in the lower four quintiles. Regression analyses showed a significant relationship between level of plasma total tau and measures of depression, apathy, anxiety, worry and sleep. The presence of higher levels of plasma tau and elevated neurobehavioral symptoms may be an early indicator of cognitive decline and prodromal Alzheimer’s disease. Longitudinal research is needed to evaluate the impact of these factors on the development of dementia and may suggest areas for early intervention.
format	article
author	James R. Hall James R. Hall Melissa Petersen Melissa Petersen Leigh Johnson Leigh Johnson Sid E. O’Bryant Sid E. O’Bryant
author_facet	James R. Hall James R. Hall Melissa Petersen Melissa Petersen Leigh Johnson Leigh Johnson Sid E. O’Bryant Sid E. O’Bryant
author_sort	James R. Hall
title	Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults
title_short	Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults
title_full	Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults
title_fullStr	Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults
title_full_unstemmed	Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults
title_sort	plasma total tau and neurobehavioral symptoms of cognitive decline in cognitively normal older adults
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/064c659f826a488fa58ad29d8c2eff75
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Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults

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