Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.

<h4>Background</h4>The development of CRS is believed to be the result of combined interactions between the genetic background of the affected subject and environmental factors.<h4>Objectives</h4>To replicate and extend our recent findings from genetic association studies in...

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Autores principales:	Yuan Zhang, Leandra Mfuna Endam, Abdelali Filali-Mouhim, Liping Zhao, Martin Desrosiers, Demin Han, Luo Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/064e84bf5bb24a0899212112c8262932
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spelling	oai:doaj.org-article:064e84bf5bb24a0899212112c82629322021-11-18T07:14:58ZPolymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.1932-620310.1371/journal.pone.0039247https://doaj.org/article/064e84bf5bb24a0899212112c82629322012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22723975/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The development of CRS is believed to be the result of combined interactions between the genetic background of the affected subject and environmental factors.<h4>Objectives</h4>To replicate and extend our recent findings from genetic association studies in chronic rhinosinusitis (CRS) performed in a Canadian Caucasian population in a Chinese population.<h4>Methods</h4>In a case-control replication study, DNA samples were obtained from CRS with (n = 306; CRSwNP) and without (n = 332; CRSsNP) nasal polyps, and controls (n = 315) in a Chinese population. A total of forty-nine single nucleotide polymorphisms (SNPs) selected from previous identified SNPs associated with CRS in Canadian population, and SNPs from the CHB HapMap dataset were individually genotyped.<h4>Results</h4>We identified two SNPs respectively in RYBP (rs4532099, p = 2.15E-06, OR = 2.59) and AOAH (rs4504543, p = 0.0001152, OR = 0.58) significantly associated with whole CRS cohort. Subgroup analysis for the presence of nasal polyps (CRSwNP and CRSsNP) displayed significant association in CRSwNP cohorts regarding to one SNP in RYBP (P = 3.24(E)-006, OR = 2.76). Evidence of association in the CRSsNP groups in terms of 2 SNPs (AOAH_rs4504543 and RYBP_rs4532099) was detected as well. Stratifying analysis by gender demonstrated that none of the selected SNPs were associated with CRSwNP as well as CRSsNP. Meanwhile 3 SNPs (IL1A_rs17561, P = 0.005778; IL1A_rs1800587, P = 0.009561; IRAK4_rs4251513, P = 0.03837) were associated with serum total IgE level.<h4>Conclusions</h4>These genes are biologically plausible, with roles in regulation of transcription (RYBP) and inflammatory response (AOAH). The present data suggests the potential common genetic basis in the development of CRS in Chinese and Caucasian population.Yuan ZhangLeandra Mfuna EndamAbdelali Filali-MouhimLiping ZhaoMartin DesrosiersDemin HanLuo ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39247 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuan Zhang Leandra Mfuna Endam Abdelali Filali-Mouhim Liping Zhao Martin Desrosiers Demin Han Luo Zhang Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.
description	<h4>Background</h4>The development of CRS is believed to be the result of combined interactions between the genetic background of the affected subject and environmental factors.<h4>Objectives</h4>To replicate and extend our recent findings from genetic association studies in chronic rhinosinusitis (CRS) performed in a Canadian Caucasian population in a Chinese population.<h4>Methods</h4>In a case-control replication study, DNA samples were obtained from CRS with (n = 306; CRSwNP) and without (n = 332; CRSsNP) nasal polyps, and controls (n = 315) in a Chinese population. A total of forty-nine single nucleotide polymorphisms (SNPs) selected from previous identified SNPs associated with CRS in Canadian population, and SNPs from the CHB HapMap dataset were individually genotyped.<h4>Results</h4>We identified two SNPs respectively in RYBP (rs4532099, p = 2.15E-06, OR = 2.59) and AOAH (rs4504543, p = 0.0001152, OR = 0.58) significantly associated with whole CRS cohort. Subgroup analysis for the presence of nasal polyps (CRSwNP and CRSsNP) displayed significant association in CRSwNP cohorts regarding to one SNP in RYBP (P = 3.24(E)-006, OR = 2.76). Evidence of association in the CRSsNP groups in terms of 2 SNPs (AOAH_rs4504543 and RYBP_rs4532099) was detected as well. Stratifying analysis by gender demonstrated that none of the selected SNPs were associated with CRSwNP as well as CRSsNP. Meanwhile 3 SNPs (IL1A_rs17561, P = 0.005778; IL1A_rs1800587, P = 0.009561; IRAK4_rs4251513, P = 0.03837) were associated with serum total IgE level.<h4>Conclusions</h4>These genes are biologically plausible, with roles in regulation of transcription (RYBP) and inflammatory response (AOAH). The present data suggests the potential common genetic basis in the development of CRS in Chinese and Caucasian population.
format	article
author	Yuan Zhang Leandra Mfuna Endam Abdelali Filali-Mouhim Liping Zhao Martin Desrosiers Demin Han Luo Zhang
author_facet	Yuan Zhang Leandra Mfuna Endam Abdelali Filali-Mouhim Liping Zhao Martin Desrosiers Demin Han Luo Zhang
author_sort	Yuan Zhang
title	Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.
title_short	Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.
title_full	Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.
title_fullStr	Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.
title_full_unstemmed	Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.
title_sort	polymorphisms in rybp and aoah genes are associated with chronic rhinosinusitis in a chinese population: a replication study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/064e84bf5bb24a0899212112c8262932
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Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study.

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