Neutrophil to lymphocyte ratio and fibrinogen values in predicting patients with type B aortic dissection

Abstract The aim of this study is to detect the diagnosis value of neutrophil lymphocyte ratio (NLR) and fibrinogen (FIB) in type B aortic dissection (TBAD) patients. This retrospective observation study consisted patients with TBAD, aortic aneurysm and physical examination between January 1, 2016 a...

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Autores principales:	Shuangshuang Li, Jin Yang, Jian Dong, Renle Guo, Sheng Chang, Hongqiao Zhu, Zhaohui Li, Jian Zhou, Zaiping Jing
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0650fd4ac4f1499d8c6224df5802329f
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spelling	oai:doaj.org-article:0650fd4ac4f1499d8c6224df5802329f2021-12-02T15:56:56ZNeutrophil to lymphocyte ratio and fibrinogen values in predicting patients with type B aortic dissection10.1038/s41598-021-90811-52045-2322https://doaj.org/article/0650fd4ac4f1499d8c6224df5802329f2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90811-5https://doaj.org/toc/2045-2322Abstract The aim of this study is to detect the diagnosis value of neutrophil lymphocyte ratio (NLR) and fibrinogen (FIB) in type B aortic dissection (TBAD) patients. This retrospective observation study consisted patients with TBAD, aortic aneurysm and physical examination between January 1, 2016 and December 31, 2019. Demographic and clinical information after the first admission were collected. Multivariate logistic regression analysis was performed to explore the correlational relationship between NLR, FIB and TBAD. Receiver Operating Characteristic Curve (ROC) was performed to evaluate the diagnostic implication of NLR and FIB in TBAD patients. Six hundred and six patients who were first diagnosed with TBAD were included. Control groups were 202 aortic aneurysm and 140 physical examination subjects. The level of NLR and FIB in aortic dissection patients was significantly higher than aortic aneurysm patients and healthy group (P < 0.001). According to the results of multivariate logistic regression analysis, NLR and FIB were independent risk factors of aortic dissection, and the odds ratio (OR) and 95% confidence interval (CI) value of NLR and FIB were 1.499 (1.126–1.738) and 1.914 (1.475–2.485), respectively. The area under the curve (AUC) was 0.836 of NLR and 0.756 of FIB. NLR and FIB showed high specificity, 89% and 83% respectively. This is the first study provided information on the diagnosis performance of NLR and FIB in TBAD patients. NLR and FIB showed high specificity, which may be a valuable tool for the diagnosis of TBAD.Shuangshuang LiJin YangJian DongRenle GuoSheng ChangHongqiao ZhuZhaohui LiJian ZhouZaiping JingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuangshuang Li Jin Yang Jian Dong Renle Guo Sheng Chang Hongqiao Zhu Zhaohui Li Jian Zhou Zaiping Jing Neutrophil to lymphocyte ratio and fibrinogen values in predicting patients with type B aortic dissection
description	Abstract The aim of this study is to detect the diagnosis value of neutrophil lymphocyte ratio (NLR) and fibrinogen (FIB) in type B aortic dissection (TBAD) patients. This retrospective observation study consisted patients with TBAD, aortic aneurysm and physical examination between January 1, 2016 and December 31, 2019. Demographic and clinical information after the first admission were collected. Multivariate logistic regression analysis was performed to explore the correlational relationship between NLR, FIB and TBAD. Receiver Operating Characteristic Curve (ROC) was performed to evaluate the diagnostic implication of NLR and FIB in TBAD patients. Six hundred and six patients who were first diagnosed with TBAD were included. Control groups were 202 aortic aneurysm and 140 physical examination subjects. The level of NLR and FIB in aortic dissection patients was significantly higher than aortic aneurysm patients and healthy group (P < 0.001). According to the results of multivariate logistic regression analysis, NLR and FIB were independent risk factors of aortic dissection, and the odds ratio (OR) and 95% confidence interval (CI) value of NLR and FIB were 1.499 (1.126–1.738) and 1.914 (1.475–2.485), respectively. The area under the curve (AUC) was 0.836 of NLR and 0.756 of FIB. NLR and FIB showed high specificity, 89% and 83% respectively. This is the first study provided information on the diagnosis performance of NLR and FIB in TBAD patients. NLR and FIB showed high specificity, which may be a valuable tool for the diagnosis of TBAD.
format	article
author	Shuangshuang Li Jin Yang Jian Dong Renle Guo Sheng Chang Hongqiao Zhu Zhaohui Li Jian Zhou Zaiping Jing
author_facet	Shuangshuang Li Jin Yang Jian Dong Renle Guo Sheng Chang Hongqiao Zhu Zhaohui Li Jian Zhou Zaiping Jing
author_sort	Shuangshuang Li
title	Neutrophil to lymphocyte ratio and fibrinogen values in predicting patients with type B aortic dissection
title_short	Neutrophil to lymphocyte ratio and fibrinogen values in predicting patients with type B aortic dissection
title_full	Neutrophil to lymphocyte ratio and fibrinogen values in predicting patients with type B aortic dissection
title_fullStr	Neutrophil to lymphocyte ratio and fibrinogen values in predicting patients with type B aortic dissection
title_full_unstemmed	Neutrophil to lymphocyte ratio and fibrinogen values in predicting patients with type B aortic dissection
title_sort	neutrophil to lymphocyte ratio and fibrinogen values in predicting patients with type b aortic dissection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0650fd4ac4f1499d8c6224df5802329f
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Neutrophil to lymphocyte ratio and fibrinogen values in predicting patients with type B aortic dissection

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