Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia

Abstract Acupuncture is an alternative treatment for wide spectrum chronic pain. However, its validity remains controversial due to the disputed efficacy assessed in various clinical studies. Moreover, variability amongst individuals complicates the predictability of outcome, which impedes the integ...

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Autores principales:	Takumi Fujita, Changyong Feng, Takahiro Takano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/065518beda2f436ab9a6a548558ae0e4
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spelling	oai:doaj.org-article:065518beda2f436ab9a6a548558ae0e42021-12-02T12:32:05ZPresence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia10.1038/s41598-017-03542-x2045-2322https://doaj.org/article/065518beda2f436ab9a6a548558ae0e42017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03542-xhttps://doaj.org/toc/2045-2322Abstract Acupuncture is an alternative treatment for wide spectrum chronic pain. However, its validity remains controversial due to the disputed efficacy assessed in various clinical studies. Moreover, variability amongst individuals complicates the predictability of outcome, which impedes the integration of acupuncture into mainstream pain management programs. In light of our previous finding that the analgesic effect of acupuncture is mediated by adenosine A1 receptor activation at the acupuncture point, we here report that in acute and chronic animal pain models, oral intake of caffeine, a potent adenosine receptor antagonist, interferes with acupuncture analgesia, even at a low dose. Local administration of caffeine at the acupuncture point was sufficient to eliminate the analgesic effect, dismissing the systemic action of caffeine. Such interference was reversible, as caffeine withdrawal fully restored the efficacy of acupuncture by the next day, and long-term exposure to caffeine did not alter A1 receptor expression at the acupuncture point. Combined, these data indicate that a trace amount of caffeine can reversibly block the analgesic effects of acupuncture, and controlling caffeine consumption during acupuncture may improve pain management outcomes.Takumi FujitaChangyong FengTakahiro TakanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takumi Fujita Changyong Feng Takahiro Takano Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia
description	Abstract Acupuncture is an alternative treatment for wide spectrum chronic pain. However, its validity remains controversial due to the disputed efficacy assessed in various clinical studies. Moreover, variability amongst individuals complicates the predictability of outcome, which impedes the integration of acupuncture into mainstream pain management programs. In light of our previous finding that the analgesic effect of acupuncture is mediated by adenosine A1 receptor activation at the acupuncture point, we here report that in acute and chronic animal pain models, oral intake of caffeine, a potent adenosine receptor antagonist, interferes with acupuncture analgesia, even at a low dose. Local administration of caffeine at the acupuncture point was sufficient to eliminate the analgesic effect, dismissing the systemic action of caffeine. Such interference was reversible, as caffeine withdrawal fully restored the efficacy of acupuncture by the next day, and long-term exposure to caffeine did not alter A1 receptor expression at the acupuncture point. Combined, these data indicate that a trace amount of caffeine can reversibly block the analgesic effects of acupuncture, and controlling caffeine consumption during acupuncture may improve pain management outcomes.
format	article
author	Takumi Fujita Changyong Feng Takahiro Takano
author_facet	Takumi Fujita Changyong Feng Takahiro Takano
author_sort	Takumi Fujita
title	Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia
title_short	Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia
title_full	Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia
title_fullStr	Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia
title_full_unstemmed	Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia
title_sort	presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/065518beda2f436ab9a6a548558ae0e4
work_keys_str_mv	AT takumifujita presenceofcaffeinereversiblyinterfereswithefficacyofacupunctureinducedanalgesia AT changyongfeng presenceofcaffeinereversiblyinterfereswithefficacyofacupunctureinducedanalgesia AT takahirotakano presenceofcaffeinereversiblyinterfereswithefficacyofacupunctureinducedanalgesia
_version_	1718394137747652608

Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia

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