Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody

Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody

Abstract We have utilized a high-diversity phage display library to engineer antibody fragments (Fabs) that can modulate the activity of the enzyme isocitrate dehydrogenase 1 (IDH1). We show that a conformation-specific Fab can reactivate an IDH1 mutant associated with brain tumors. The results show...

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Autores principales: Shahir S. Rizk, Somnath Mukherjee, Akiko Koide, Shohei Koide, Anthony A. Kossiakoff
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/065572b166404feeb3517918ff5de3c8
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