Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.

Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.

Generally, epithelial cells must organize in three dimensions to form functional tissue sheets. Here we investigate one such sheet, the Drosophila embryonic epidermis, and the morphogenetic processes organizing cells within it. We report that epidermal morphogenesis requires the proper distribution...

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Autores principales: Nicole A Kaplan, Pamela F Colosimo, Xiaoping Liu, Nicholas S Tolwinski
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/0659ab3de17248208aadb139825d7dfa
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spelling oai:doaj.org-article:0659ab3de17248208aadb139825d7dfa2021-11-18T06:56:15ZComplex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.1932-620310.1371/journal.pone.0018616https://doaj.org/article/0659ab3de17248208aadb139825d7dfa2011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21483653/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Generally, epithelial cells must organize in three dimensions to form functional tissue sheets. Here we investigate one such sheet, the Drosophila embryonic epidermis, and the morphogenetic processes organizing cells within it. We report that epidermal morphogenesis requires the proper distribution of the apical polarity determinant aPKC. Specifically, we find roles for the kinases GSK3 and aPKC in cellular alignment, asymmetric protein distribution, and adhesion during the development of this polarized tissue. Finally, we propose a model explaining how regulation of aPKC protein levels can reorganize both adhesion and the cytoskeleton.Nicole A KaplanPamela F ColosimoXiaoping LiuNicholas S TolwinskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e18616 (2011)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Nicole A Kaplan
Pamela F Colosimo
Xiaoping Liu
Nicholas S Tolwinski
Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.
description Generally, epithelial cells must organize in three dimensions to form functional tissue sheets. Here we investigate one such sheet, the Drosophila embryonic epidermis, and the morphogenetic processes organizing cells within it. We report that epidermal morphogenesis requires the proper distribution of the apical polarity determinant aPKC. Specifically, we find roles for the kinases GSK3 and aPKC in cellular alignment, asymmetric protein distribution, and adhesion during the development of this polarized tissue. Finally, we propose a model explaining how regulation of aPKC protein levels can reorganize both adhesion and the cytoskeleton.
format article
author Nicole A Kaplan
Pamela F Colosimo
Xiaoping Liu
Nicholas S Tolwinski
author_facet Nicole A Kaplan
Pamela F Colosimo
Xiaoping Liu
Nicholas S Tolwinski
author_sort Nicole A Kaplan
title Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.
title_short Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.
title_full Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.
title_fullStr Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.
title_full_unstemmed Complex interactions between GSK3 and aPKC in Drosophila embryonic epithelial morphogenesis.
title_sort complex interactions between gsk3 and apkc in drosophila embryonic epithelial morphogenesis.
publisher Public Library of Science (PLoS)
publishDate 2011
url https://doaj.org/article/0659ab3de17248208aadb139825d7dfa
work_keys_str_mv AT nicoleakaplan complexinteractionsbetweengsk3andapkcindrosophilaembryonicepithelialmorphogenesis
AT pamelafcolosimo complexinteractionsbetweengsk3andapkcindrosophilaembryonicepithelialmorphogenesis
AT xiaopingliu complexinteractionsbetweengsk3andapkcindrosophilaembryonicepithelialmorphogenesis
AT nicholasstolwinski complexinteractionsbetweengsk3andapkcindrosophilaembryonicepithelialmorphogenesis
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