Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer

Human telomeres are protected by a specialized shelterin complex composed of six proteins. Here the authors structurally characterize the interaction between the POT1-TPP1 shelterin component and identify mutations associated with genome instability and cancer that disrupt the POT1-TPP1 interaction.

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Autores principales:	Cong Chen, Peili Gu, Jian Wu, Xianyun Chen, Shuangshuang Niu, Hong Sun, Lijie Wu, Na Li, Junhui Peng, Shaohua Shi, Cuiying Fan, Min Huang, Catherine C. L. Wong, Qingguo Gong, Chandan Kumar-Sinha, Rongguang Zhang, Lajos Pusztai, Rekha Rai, Sandy Chang, Ming Lei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/065abaa24dae41b98a5a598499b77503
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spelling	oai:doaj.org-article:065abaa24dae41b98a5a598499b775032021-12-02T14:42:25ZStructural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer10.1038/ncomms149292041-1723https://doaj.org/article/065abaa24dae41b98a5a598499b775032017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14929https://doaj.org/toc/2041-1723Human telomeres are protected by a specialized shelterin complex composed of six proteins. Here the authors structurally characterize the interaction between the POT1-TPP1 shelterin component and identify mutations associated with genome instability and cancer that disrupt the POT1-TPP1 interaction.Cong ChenPeili GuJian WuXianyun ChenShuangshuang NiuHong SunLijie WuNa LiJunhui PengShaohua ShiCuiying FanMin HuangCatherine C. L. WongQingguo GongChandan Kumar-SinhaRongguang ZhangLajos PusztaiRekha RaiSandy ChangMing LeiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cong Chen Peili Gu Jian Wu Xianyun Chen Shuangshuang Niu Hong Sun Lijie Wu Na Li Junhui Peng Shaohua Shi Cuiying Fan Min Huang Catherine C. L. Wong Qingguo Gong Chandan Kumar-Sinha Rongguang Zhang Lajos Pusztai Rekha Rai Sandy Chang Ming Lei Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
description	Human telomeres are protected by a specialized shelterin complex composed of six proteins. Here the authors structurally characterize the interaction between the POT1-TPP1 shelterin component and identify mutations associated with genome instability and cancer that disrupt the POT1-TPP1 interaction.
format	article
author	Cong Chen Peili Gu Jian Wu Xianyun Chen Shuangshuang Niu Hong Sun Lijie Wu Na Li Junhui Peng Shaohua Shi Cuiying Fan Min Huang Catherine C. L. Wong Qingguo Gong Chandan Kumar-Sinha Rongguang Zhang Lajos Pusztai Rekha Rai Sandy Chang Ming Lei
author_facet	Cong Chen Peili Gu Jian Wu Xianyun Chen Shuangshuang Niu Hong Sun Lijie Wu Na Li Junhui Peng Shaohua Shi Cuiying Fan Min Huang Catherine C. L. Wong Qingguo Gong Chandan Kumar-Sinha Rongguang Zhang Lajos Pusztai Rekha Rai Sandy Chang Ming Lei
author_sort	Cong Chen
title	Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
title_short	Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
title_full	Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
title_fullStr	Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
title_full_unstemmed	Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
title_sort	structural insights into pot1-tpp1 interaction and pot1 c-terminal mutations in human cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/065abaa24dae41b98a5a598499b77503
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Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer

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