Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
Human telomeres are protected by a specialized shelterin complex composed of six proteins. Here the authors structurally characterize the interaction between the POT1-TPP1 shelterin component and identify mutations associated with genome instability and cancer that disrupt the POT1-TPP1 interaction.
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/065abaa24dae41b98a5a598499b77503 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|