Reduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression

Toshiyuki Ohtani,1– 3 Koji Matsuo,4 Chihiro Sutoh,5 Fumiyo Oshima,2,3 Yoshiyuki Hirano,2,3 Akio Wakabayashi,6 Eiji Shimizu2,3,5 1Safety and Health Organization, Chiba University, Chiba, Japan; 2Research Center for Child Mental Development, Chiba University, Chiba, Japan; 3United Graduate School of C...

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Autores principales:	Ohtani T, Matsuo K, Sutoh C, Oshima F, Hirano Y, Wakabayashi A, Shimizu E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	autism spectrum disorder depression comorbidity functional near-infrared spectroscopy emotional face recognition social cognition frontotemporal activation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/065af91a14bb4a83b14d0f1d9b9eada7
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spelling	oai:doaj.org-article:065af91a14bb4a83b14d0f1d9b9eada72021-12-02T17:29:55ZReduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression1178-2021https://doaj.org/article/065af91a14bb4a83b14d0f1d9b9eada72021-09-01T00:00:00Zhttps://www.dovepress.com/reduced-brain-activation-in-response-to-social-cognition-tasks-in-auti-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Toshiyuki Ohtani,1– 3 Koji Matsuo,4 Chihiro Sutoh,5 Fumiyo Oshima,2,3 Yoshiyuki Hirano,2,3 Akio Wakabayashi,6 Eiji Shimizu2,3,5 1Safety and Health Organization, Chiba University, Chiba, Japan; 2Research Center for Child Mental Development, Chiba University, Chiba, Japan; 3United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan; 4Department of Psychiatry, Faculty of Medicine, Saitama Medical University, Saitama, Japan; 5Department of Cognitive Behavioral Physiology, Graduate School of Medicine and School of Medicine, Chiba University, Chiba University, Chiba, Japan; 6Department of Psychology,Graduate School of Humanities, Chiba University, Chiba, JapanCorrespondence: Toshiyuki OhtaniSafety and Health Organization, Chiba University, 1-33 Yayoicho, Inage-ku, Chiba, 263-8522, JapanTel/Fax +81 43 290 2216Email otanit@Chiba-u.jpPurpose: In clinical settings, diagnosing comorbid depression in individuals with autism spectrum disorder (ASD) is often difficult. Neuroimaging studies have reported reduced activation of frontal and temporal regions during emotional face recognition task (EFRT) in ASD and depression. However, to the best of our knowledge, no study has examined differences in frontotemporal activation during EFRT between ASD with and without comorbid depression. We aimed to compare the frontotemporal hemodynamic responses to the EFRT in ASD with and without depression and to find clues to help in discriminating the characteristics between them.Patients and Methods: In 24 drug-naïve young adults with ASD (12 with depression [ASD-Dep(+)] and 12 without depression [ASD-Dep(-)]) and 12 with typical development (TD), frontotemporal hemodynamic responses during an EFRT were measured using functional near-infrared spectroscopy (fNIRS).Results: The ASD groups showed reduced activation during EFRT than the TD group in the right ventrolateral prefrontal cortex (VLPFC). Moreover, the ASD-Dep(+) group showed reduced activation during EFRT than the ASD-Dep(-) group in the right anterior temporal cortex (aTC), and reduced activation than the TD group in the left VLPFC.Conclusion: The observed results might reflect reduced regional activation in ASD and ASD with comorbid depression.Keywords: autism spectrum disorder, depression comorbidity, functional near-infrared spectroscopy, emotional face recognition, social cognition, frontotemporal activationOhtani TMatsuo KSutoh COshima FHirano YWakabayashi AShimizu EDove Medical Pressarticleautism spectrum disorderdepression comorbidityfunctional near-infrared spectroscopyemotional face recognitionsocial cognitionfrontotemporal activationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 3015-3024 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism spectrum disorder depression comorbidity functional near-infrared spectroscopy emotional face recognition social cognition frontotemporal activation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	autism spectrum disorder depression comorbidity functional near-infrared spectroscopy emotional face recognition social cognition frontotemporal activation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ohtani T Matsuo K Sutoh C Oshima F Hirano Y Wakabayashi A Shimizu E Reduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression
description	Toshiyuki Ohtani,1– 3 Koji Matsuo,4 Chihiro Sutoh,5 Fumiyo Oshima,2,3 Yoshiyuki Hirano,2,3 Akio Wakabayashi,6 Eiji Shimizu2,3,5 1Safety and Health Organization, Chiba University, Chiba, Japan; 2Research Center for Child Mental Development, Chiba University, Chiba, Japan; 3United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan; 4Department of Psychiatry, Faculty of Medicine, Saitama Medical University, Saitama, Japan; 5Department of Cognitive Behavioral Physiology, Graduate School of Medicine and School of Medicine, Chiba University, Chiba University, Chiba, Japan; 6Department of Psychology,Graduate School of Humanities, Chiba University, Chiba, JapanCorrespondence: Toshiyuki OhtaniSafety and Health Organization, Chiba University, 1-33 Yayoicho, Inage-ku, Chiba, 263-8522, JapanTel/Fax +81 43 290 2216Email otanit@Chiba-u.jpPurpose: In clinical settings, diagnosing comorbid depression in individuals with autism spectrum disorder (ASD) is often difficult. Neuroimaging studies have reported reduced activation of frontal and temporal regions during emotional face recognition task (EFRT) in ASD and depression. However, to the best of our knowledge, no study has examined differences in frontotemporal activation during EFRT between ASD with and without comorbid depression. We aimed to compare the frontotemporal hemodynamic responses to the EFRT in ASD with and without depression and to find clues to help in discriminating the characteristics between them.Patients and Methods: In 24 drug-naïve young adults with ASD (12 with depression [ASD-Dep(+)] and 12 without depression [ASD-Dep(-)]) and 12 with typical development (TD), frontotemporal hemodynamic responses during an EFRT were measured using functional near-infrared spectroscopy (fNIRS).Results: The ASD groups showed reduced activation during EFRT than the TD group in the right ventrolateral prefrontal cortex (VLPFC). Moreover, the ASD-Dep(+) group showed reduced activation during EFRT than the ASD-Dep(-) group in the right anterior temporal cortex (aTC), and reduced activation than the TD group in the left VLPFC.Conclusion: The observed results might reflect reduced regional activation in ASD and ASD with comorbid depression.Keywords: autism spectrum disorder, depression comorbidity, functional near-infrared spectroscopy, emotional face recognition, social cognition, frontotemporal activation
format	article
author	Ohtani T Matsuo K Sutoh C Oshima F Hirano Y Wakabayashi A Shimizu E
author_facet	Ohtani T Matsuo K Sutoh C Oshima F Hirano Y Wakabayashi A Shimizu E
author_sort	Ohtani T
title	Reduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression
title_short	Reduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression
title_full	Reduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression
title_fullStr	Reduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression
title_full_unstemmed	Reduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression
title_sort	reduced brain activation in response to social cognition tasks in autism spectrum disorder with and without depression
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/065af91a14bb4a83b14d0f1d9b9eada7
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Reduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression

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