Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers

Tumor treating fields (TTFields)-an intermediate-frequency, electric field therapy-has emerged as a promising alternative therapy for the treatment of solid cancers. Since the first publication describing the anticancer effects of TTFields in 2004 there have been numerous follow-up studies by other...

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Autores principales:	Travis H. Jones, Jonathan W. Song, Laith Abushahin
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Electromagnetic fields Physical oncology Tumor microenvironment Thoracic and abdominal cavity cancer TTFields Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/065e1fa11fc048d482006c7cb82aa3bf
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spelling	oai:doaj.org-article:065e1fa11fc048d482006c7cb82aa3bf2021-11-28T04:29:58ZTumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers1936-523310.1016/j.tranon.2021.101296https://doaj.org/article/065e1fa11fc048d482006c7cb82aa3bf2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1936523321002874https://doaj.org/toc/1936-5233Tumor treating fields (TTFields)-an intermediate-frequency, electric field therapy-has emerged as a promising alternative therapy for the treatment of solid cancers. Since the first publication describing the anticancer effects of TTFields in 2004 there have been numerous follow-up studies by other groups, either to confirm the efficacy of TTFields or to study the primary mechanism of interaction. The overwhelming conclusion from these in vitro studies is that TTFields reduce the viability of aggressively replicating cell lines. However, there is still speculation as to the primary mechanism for this effect; moreover, observations both in vitro and in vivo of inhibited migration and metastases have been made, which may be unrelated to the originally proposed hypothesis of replication stress. Adding to this, the in vivo environment is much more complex spatially, structurally, and involves intricate networks of cell signaling, all of which could change the efficacy of TTFields in the same way pharmaceutical interventions often struggle transitioning in vivo. Despite this, TTFields have shown promise in clinical practice on multiple cancer types, which begs the question: has the primary mechanism carried over from in vitro to in vivo or are there new mechanisms at play? The goal of this review is to highlight the current proposed mechanism of action of TTFields based primarily on in vitro experiments and animal models, provide a summary of the clinical efficacy of TTFields, and finally, propose future directions of research to identify all possible mechanisms in vivo utilizing novel tumor-on-a-chip platforms.Travis H. JonesJonathan W. SongLaith AbushahinElsevierarticleElectromagnetic fieldsPhysical oncologyTumor microenvironmentThoracic and abdominal cavity cancerTTFieldsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTranslational Oncology, Vol 15, Iss 1, Pp 101296- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Electromagnetic fields Physical oncology Tumor microenvironment Thoracic and abdominal cavity cancer TTFields Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Electromagnetic fields Physical oncology Tumor microenvironment Thoracic and abdominal cavity cancer TTFields Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Travis H. Jones Jonathan W. Song Laith Abushahin Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers
description	Tumor treating fields (TTFields)-an intermediate-frequency, electric field therapy-has emerged as a promising alternative therapy for the treatment of solid cancers. Since the first publication describing the anticancer effects of TTFields in 2004 there have been numerous follow-up studies by other groups, either to confirm the efficacy of TTFields or to study the primary mechanism of interaction. The overwhelming conclusion from these in vitro studies is that TTFields reduce the viability of aggressively replicating cell lines. However, there is still speculation as to the primary mechanism for this effect; moreover, observations both in vitro and in vivo of inhibited migration and metastases have been made, which may be unrelated to the originally proposed hypothesis of replication stress. Adding to this, the in vivo environment is much more complex spatially, structurally, and involves intricate networks of cell signaling, all of which could change the efficacy of TTFields in the same way pharmaceutical interventions often struggle transitioning in vivo. Despite this, TTFields have shown promise in clinical practice on multiple cancer types, which begs the question: has the primary mechanism carried over from in vitro to in vivo or are there new mechanisms at play? The goal of this review is to highlight the current proposed mechanism of action of TTFields based primarily on in vitro experiments and animal models, provide a summary of the clinical efficacy of TTFields, and finally, propose future directions of research to identify all possible mechanisms in vivo utilizing novel tumor-on-a-chip platforms.
format	article
author	Travis H. Jones Jonathan W. Song Laith Abushahin
author_facet	Travis H. Jones Jonathan W. Song Laith Abushahin
author_sort	Travis H. Jones
title	Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers
title_short	Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers
title_full	Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers
title_fullStr	Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers
title_full_unstemmed	Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers
title_sort	tumor treating fields: an emerging treatment modality for thoracic and abdominal cavity cancers
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/065e1fa11fc048d482006c7cb82aa3bf
work_keys_str_mv	AT travishjones tumortreatingfieldsanemergingtreatmentmodalityforthoracicandabdominalcavitycancers AT jonathanwsong tumortreatingfieldsanemergingtreatmentmodalityforthoracicandabdominalcavitycancers AT laithabushahin tumortreatingfieldsanemergingtreatmentmodalityforthoracicandabdominalcavitycancers
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Tumor treating fields: An emerging treatment modality for thoracic and abdominal cavity cancers

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