Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression

Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to se...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cornelia Tolg, Britney Jodi-Ann Messam, James Benjamin McCarthy, Andrew Cook Nelson, Eva Ann Turley
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hyaluronan RHAMM CD44 wound repair breast cancer Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/065f3a6a375e4378a6b9f9199a8e0190
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:065f3a6a375e4378a6b9f9199a8e0190
record_format	dspace
spelling	oai:doaj.org-article:065f3a6a375e4378a6b9f9199a8e01902021-11-25T16:51:43ZHyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression10.3390/biom111115512218-273Xhttps://doaj.org/article/065f3a6a375e4378a6b9f9199a8e01902021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1551https://doaj.org/toc/2218-273XSignaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression.Cornelia TolgBritney Jodi-Ann MessamJames Benjamin McCarthyAndrew Cook NelsonEva Ann TurleyMDPI AGarticlehyaluronanRHAMMCD44wound repairbreast cancerMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1551, p 1551 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyaluronan RHAMM CD44 wound repair breast cancer Microbiology QR1-502
spellingShingle	hyaluronan RHAMM CD44 wound repair breast cancer Microbiology QR1-502 Cornelia Tolg Britney Jodi-Ann Messam James Benjamin McCarthy Andrew Cook Nelson Eva Ann Turley Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
description	Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression.
format	article
author	Cornelia Tolg Britney Jodi-Ann Messam James Benjamin McCarthy Andrew Cook Nelson Eva Ann Turley
author_facet	Cornelia Tolg Britney Jodi-Ann Messam James Benjamin McCarthy Andrew Cook Nelson Eva Ann Turley
author_sort	Cornelia Tolg
title	Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
title_short	Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
title_full	Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
title_fullStr	Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
title_full_unstemmed	Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression
title_sort	hyaluronan functions in wound repair that are captured to fuel breast cancer progression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/065f3a6a375e4378a6b9f9199a8e0190
work_keys_str_mv	AT corneliatolg hyaluronanfunctionsinwoundrepairthatarecapturedtofuelbreastcancerprogression AT britneyjodiannmessam hyaluronanfunctionsinwoundrepairthatarecapturedtofuelbreastcancerprogression AT jamesbenjaminmccarthy hyaluronanfunctionsinwoundrepairthatarecapturedtofuelbreastcancerprogression AT andrewcooknelson hyaluronanfunctionsinwoundrepairthatarecapturedtofuelbreastcancerprogression AT evaannturley hyaluronanfunctionsinwoundrepairthatarecapturedtofuelbreastcancerprogression
_version_	1718412876759171072

Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression

Ejemplares similares