Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Gestational duration depends on both maternal and fetal genetic influences. Here, the authors perform a fetal genome-wide association meta-analysis and find that a locus on 2q13 is associated with pregnancy duration and further show that the lead SNP rs7594852 changes the binding properties of trans...

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Autores principales:	Xueping Liu, Dorte Helenius, Line Skotte, Robin N. Beaumont, Matthias Wielscher, Frank Geller, Julius Juodakis, Anubha Mahajan, Jonathan P. Bradfield, Frederick T. J. Lin, Suzanne Vogelezang, Mariona Bustamante, Tarunveer S. Ahluwalia, Niina Pitkänen, Carol A. Wang, Jonas Bacelis, Maria C. Borges, Ge Zhang, Bruce A. Bedell, Robert M. Rossi, Kristin Skogstrand, Shouneng Peng, Wesley K. Thompson, Vivek Appadurai, Debbie A. Lawlor, Ilkka Kalliala, Christine Power, Mark I. McCarthy, Heather A. Boyd, Mary L. Marazita, Hakon Hakonarson, M. Geoffrey Hayes, Denise M. Scholtens, Fernando Rivadeneira, Vincent W. V. Jaddoe, Rebecca K. Vinding, Hans Bisgaard, Bridget A. Knight, Katja Pahkala, Olli Raitakari, Øyvind Helgeland, Stefan Johansson, Pål R. Njølstad, João Fadista, Andrew J. Schork, Ron Nudel, Daniel E. Miller, Xiaoting Chen, Matthew T. Weirauch, Preben Bo Mortensen, Anders D. Børglum, Merete Nordentoft, Ole Mors, Ke Hao, Kelli K. Ryckman, David M. Hougaard, Leah C. Kottyan, Craig E. Pennell, Leo-Pekka Lyytikainen, Klaus Bønnelykke, Martine Vrijheid, Janine F. Felix, William L. Lowe, Struan F. A. Grant, Elina Hyppönen, Bo Jacobsson, Marjo-Riitta Jarvelin, Louis J. Muglia, Jeffrey C. Murray, Rachel M. Freathy, Thomas M. Werge, Mads Melbye, Alfonso Buil, Bjarke Feenstra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0663e700e52e44dd96778ff7a9670192
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spelling	oai:doaj.org-article:0663e700e52e44dd96778ff7a96701922021-12-02T16:58:24ZVariants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration10.1038/s41467-019-11881-82041-1723https://doaj.org/article/0663e700e52e44dd96778ff7a96701922019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11881-8https://doaj.org/toc/2041-1723Gestational duration depends on both maternal and fetal genetic influences. Here, the authors perform a fetal genome-wide association meta-analysis and find that a locus on 2q13 is associated with pregnancy duration and further show that the lead SNP rs7594852 changes the binding properties of transcriptional repressor HIC1.Xueping LiuDorte HeleniusLine SkotteRobin N. BeaumontMatthias WielscherFrank GellerJulius JuodakisAnubha MahajanJonathan P. BradfieldFrederick T. J. LinSuzanne VogelezangMariona BustamanteTarunveer S. AhluwaliaNiina PitkänenCarol A. WangJonas BacelisMaria C. BorgesGe ZhangBruce A. BedellRobert M. RossiKristin SkogstrandShouneng PengWesley K. ThompsonVivek AppaduraiDebbie A. LawlorIlkka KallialaChristine PowerMark I. McCarthyHeather A. BoydMary L. MarazitaHakon HakonarsonM. Geoffrey HayesDenise M. ScholtensFernando RivadeneiraVincent W. V. JaddoeRebecca K. VindingHans BisgaardBridget A. KnightKatja PahkalaOlli RaitakariØyvind HelgelandStefan JohanssonPål R. NjølstadJoão FadistaAndrew J. SchorkRon NudelDaniel E. MillerXiaoting ChenMatthew T. WeirauchPreben Bo MortensenAnders D. BørglumMerete NordentoftOle MorsKe HaoKelli K. RyckmanDavid M. HougaardLeah C. KottyanCraig E. PennellLeo-Pekka LyytikainenKlaus BønnelykkeMartine VrijheidJanine F. FelixWilliam L. LoweStruan F. A. GrantElina HyppönenBo JacobssonMarjo-Riitta JarvelinLouis J. MugliaJeffrey C. MurrayRachel M. FreathyThomas M. WergeMads MelbyeAlfonso BuilBjarke FeenstraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xueping Liu Dorte Helenius Line Skotte Robin N. Beaumont Matthias Wielscher Frank Geller Julius Juodakis Anubha Mahajan Jonathan P. Bradfield Frederick T. J. Lin Suzanne Vogelezang Mariona Bustamante Tarunveer S. Ahluwalia Niina Pitkänen Carol A. Wang Jonas Bacelis Maria C. Borges Ge Zhang Bruce A. Bedell Robert M. Rossi Kristin Skogstrand Shouneng Peng Wesley K. Thompson Vivek Appadurai Debbie A. Lawlor Ilkka Kalliala Christine Power Mark I. McCarthy Heather A. Boyd Mary L. Marazita Hakon Hakonarson M. Geoffrey Hayes Denise M. Scholtens Fernando Rivadeneira Vincent W. V. Jaddoe Rebecca K. Vinding Hans Bisgaard Bridget A. Knight Katja Pahkala Olli Raitakari Øyvind Helgeland Stefan Johansson Pål R. Njølstad João Fadista Andrew J. Schork Ron Nudel Daniel E. Miller Xiaoting Chen Matthew T. Weirauch Preben Bo Mortensen Anders D. Børglum Merete Nordentoft Ole Mors Ke Hao Kelli K. Ryckman David M. Hougaard Leah C. Kottyan Craig E. Pennell Leo-Pekka Lyytikainen Klaus Bønnelykke Martine Vrijheid Janine F. Felix William L. Lowe Struan F. A. Grant Elina Hyppönen Bo Jacobsson Marjo-Riitta Jarvelin Louis J. Muglia Jeffrey C. Murray Rachel M. Freathy Thomas M. Werge Mads Melbye Alfonso Buil Bjarke Feenstra Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
description	Gestational duration depends on both maternal and fetal genetic influences. Here, the authors perform a fetal genome-wide association meta-analysis and find that a locus on 2q13 is associated with pregnancy duration and further show that the lead SNP rs7594852 changes the binding properties of transcriptional repressor HIC1.
format	article
author	Xueping Liu Dorte Helenius Line Skotte Robin N. Beaumont Matthias Wielscher Frank Geller Julius Juodakis Anubha Mahajan Jonathan P. Bradfield Frederick T. J. Lin Suzanne Vogelezang Mariona Bustamante Tarunveer S. Ahluwalia Niina Pitkänen Carol A. Wang Jonas Bacelis Maria C. Borges Ge Zhang Bruce A. Bedell Robert M. Rossi Kristin Skogstrand Shouneng Peng Wesley K. Thompson Vivek Appadurai Debbie A. Lawlor Ilkka Kalliala Christine Power Mark I. McCarthy Heather A. Boyd Mary L. Marazita Hakon Hakonarson M. Geoffrey Hayes Denise M. Scholtens Fernando Rivadeneira Vincent W. V. Jaddoe Rebecca K. Vinding Hans Bisgaard Bridget A. Knight Katja Pahkala Olli Raitakari Øyvind Helgeland Stefan Johansson Pål R. Njølstad João Fadista Andrew J. Schork Ron Nudel Daniel E. Miller Xiaoting Chen Matthew T. Weirauch Preben Bo Mortensen Anders D. Børglum Merete Nordentoft Ole Mors Ke Hao Kelli K. Ryckman David M. Hougaard Leah C. Kottyan Craig E. Pennell Leo-Pekka Lyytikainen Klaus Bønnelykke Martine Vrijheid Janine F. Felix William L. Lowe Struan F. A. Grant Elina Hyppönen Bo Jacobsson Marjo-Riitta Jarvelin Louis J. Muglia Jeffrey C. Murray Rachel M. Freathy Thomas M. Werge Mads Melbye Alfonso Buil Bjarke Feenstra
author_facet	Xueping Liu Dorte Helenius Line Skotte Robin N. Beaumont Matthias Wielscher Frank Geller Julius Juodakis Anubha Mahajan Jonathan P. Bradfield Frederick T. J. Lin Suzanne Vogelezang Mariona Bustamante Tarunveer S. Ahluwalia Niina Pitkänen Carol A. Wang Jonas Bacelis Maria C. Borges Ge Zhang Bruce A. Bedell Robert M. Rossi Kristin Skogstrand Shouneng Peng Wesley K. Thompson Vivek Appadurai Debbie A. Lawlor Ilkka Kalliala Christine Power Mark I. McCarthy Heather A. Boyd Mary L. Marazita Hakon Hakonarson M. Geoffrey Hayes Denise M. Scholtens Fernando Rivadeneira Vincent W. V. Jaddoe Rebecca K. Vinding Hans Bisgaard Bridget A. Knight Katja Pahkala Olli Raitakari Øyvind Helgeland Stefan Johansson Pål R. Njølstad João Fadista Andrew J. Schork Ron Nudel Daniel E. Miller Xiaoting Chen Matthew T. Weirauch Preben Bo Mortensen Anders D. Børglum Merete Nordentoft Ole Mors Ke Hao Kelli K. Ryckman David M. Hougaard Leah C. Kottyan Craig E. Pennell Leo-Pekka Lyytikainen Klaus Bønnelykke Martine Vrijheid Janine F. Felix William L. Lowe Struan F. A. Grant Elina Hyppönen Bo Jacobsson Marjo-Riitta Jarvelin Louis J. Muglia Jeffrey C. Murray Rachel M. Freathy Thomas M. Werge Mads Melbye Alfonso Buil Bjarke Feenstra
author_sort	Xueping Liu
title	Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
title_short	Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
title_full	Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
title_fullStr	Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
title_full_unstemmed	Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
title_sort	variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0663e700e52e44dd96778ff7a9670192
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Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

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