Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

Abstract The APOBEC3 (A3) family of human cytidine deaminases is renowned for providing a first line of defense against many exogenous and endogenous retroviruses. However, the ability of these proteins to deaminate deoxycytidines in ssDNA makes A3s a double-edged sword. When overexpressed, A3s can...

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Autores principales: Tania V. Silvas, Shurong Hou, Wazo Myint, Ellen Nalivaika, Mohan Somasundaran, Brian A. Kelch, Hiroshi Matsuo, Nese Kurt Yilmaz, Celia A. Schiffer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/0666f6b6aeeb4da28babab14046087f4
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