Your resting brain CAREs about your risky behavior.

<h4>Background</h4>Research on the neural correlates of risk-related behaviors and personality traits has provided insight into mechanisms underlying both normal and pathological decision-making. Task-based neuroimaging studies implicate a distributed network of brain regions in risky de...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christine L Cox, Kristin Gotimer, Amy K Roy, F Xavier Castellanos, Michael P Milham, Clare Kelly
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/066951b31a00494587e2b19c110a87e0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:066951b31a00494587e2b19c110a87e0
record_format	dspace
spelling	oai:doaj.org-article:066951b31a00494587e2b19c110a87e02021-11-18T06:35:52ZYour resting brain CAREs about your risky behavior.1932-620310.1371/journal.pone.0012296https://doaj.org/article/066951b31a00494587e2b19c110a87e02010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808870/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Research on the neural correlates of risk-related behaviors and personality traits has provided insight into mechanisms underlying both normal and pathological decision-making. Task-based neuroimaging studies implicate a distributed network of brain regions in risky decision-making. What remains to be understood are the interactions between these regions and their relation to individual differences in personality variables associated with real-world risk-taking.<h4>Methodology/principal findings</h4>We employed resting state functional magnetic resonance imaging (R-fMRI) and resting state functional connectivity (RSFC) methods to investigate differences in the brain's intrinsic functional architecture associated with beliefs about the consequences of risky behavior. We obtained an individual measure of expected benefit from engaging in risky behavior, indicating a risk seeking or risk-averse personality, for each of 21 participants from whom we also collected a series of R-fMRI scans. The expected benefit scores were entered in statistical models assessing the RSFC of brain regions consistently implicated in both the evaluation of risk and reward, and cognitive control (i.e., orbitofrontal cortex, nucleus accumbens, lateral prefrontal cortex, dorsal anterior cingulate). We specifically focused on significant brain-behavior relationships that were stable across R-fMRI scans collected one year apart. Two stable expected benefit-RSFC relationships were observed: decreased expected benefit (increased risk-aversion) was associated with 1) stronger positive functional connectivity between right inferior frontal gyrus (IFG) and right insula, and 2) weaker negative functional connectivity between left nucleus accumbens and right parieto-occipital cortex.<h4>Conclusions/significance</h4>Task-based activation in the IFG and insula has been associated with risk-aversion, while activation in the nucleus accumbens and parietal cortex has been associated with both risk seeking and risk-averse tendencies. Our results suggest that individual differences in attitudes toward risk-taking are reflected in the brain's functional architecture and may have implications for engaging in real-world risky behaviors.Christine L CoxKristin GotimerAmy K RoyF Xavier CastellanosMichael P MilhamClare KellyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 8, p e12296 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christine L Cox Kristin Gotimer Amy K Roy F Xavier Castellanos Michael P Milham Clare Kelly Your resting brain CAREs about your risky behavior.
description	<h4>Background</h4>Research on the neural correlates of risk-related behaviors and personality traits has provided insight into mechanisms underlying both normal and pathological decision-making. Task-based neuroimaging studies implicate a distributed network of brain regions in risky decision-making. What remains to be understood are the interactions between these regions and their relation to individual differences in personality variables associated with real-world risk-taking.<h4>Methodology/principal findings</h4>We employed resting state functional magnetic resonance imaging (R-fMRI) and resting state functional connectivity (RSFC) methods to investigate differences in the brain's intrinsic functional architecture associated with beliefs about the consequences of risky behavior. We obtained an individual measure of expected benefit from engaging in risky behavior, indicating a risk seeking or risk-averse personality, for each of 21 participants from whom we also collected a series of R-fMRI scans. The expected benefit scores were entered in statistical models assessing the RSFC of brain regions consistently implicated in both the evaluation of risk and reward, and cognitive control (i.e., orbitofrontal cortex, nucleus accumbens, lateral prefrontal cortex, dorsal anterior cingulate). We specifically focused on significant brain-behavior relationships that were stable across R-fMRI scans collected one year apart. Two stable expected benefit-RSFC relationships were observed: decreased expected benefit (increased risk-aversion) was associated with 1) stronger positive functional connectivity between right inferior frontal gyrus (IFG) and right insula, and 2) weaker negative functional connectivity between left nucleus accumbens and right parieto-occipital cortex.<h4>Conclusions/significance</h4>Task-based activation in the IFG and insula has been associated with risk-aversion, while activation in the nucleus accumbens and parietal cortex has been associated with both risk seeking and risk-averse tendencies. Our results suggest that individual differences in attitudes toward risk-taking are reflected in the brain's functional architecture and may have implications for engaging in real-world risky behaviors.
format	article
author	Christine L Cox Kristin Gotimer Amy K Roy F Xavier Castellanos Michael P Milham Clare Kelly
author_facet	Christine L Cox Kristin Gotimer Amy K Roy F Xavier Castellanos Michael P Milham Clare Kelly
author_sort	Christine L Cox
title	Your resting brain CAREs about your risky behavior.
title_short	Your resting brain CAREs about your risky behavior.
title_full	Your resting brain CAREs about your risky behavior.
title_fullStr	Your resting brain CAREs about your risky behavior.
title_full_unstemmed	Your resting brain CAREs about your risky behavior.
title_sort	your resting brain cares about your risky behavior.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/066951b31a00494587e2b19c110a87e0
work_keys_str_mv	AT christinelcox yourrestingbraincaresaboutyourriskybehavior AT kristingotimer yourrestingbraincaresaboutyourriskybehavior AT amykroy yourrestingbraincaresaboutyourriskybehavior AT fxaviercastellanos yourrestingbraincaresaboutyourriskybehavior AT michaelpmilham yourrestingbraincaresaboutyourriskybehavior AT clarekelly yourrestingbraincaresaboutyourriskybehavior
_version_	1718424395144232960

Your resting brain CAREs about your risky behavior.

Ejemplares similares