Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software

How gene regulatory pathways control cell fate decisions in single cells is not fully understood. Here the authors present an integrated dual-input microfluidic chip and a linked analysis software, enabling tracking of gene regulatory responses of single bacterial cells to changing conditions.

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Autores principales:	Matthias Kaiser, Florian Jug, Thomas Julou, Siddharth Deshpande, Thomas Pfohl, Olin K. Silander, Gene Myers, Erik van Nimwegen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/066a24f172fb44468bc65e725b60b53d
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id	oai:doaj.org-article:066a24f172fb44468bc65e725b60b53d
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spelling	oai:doaj.org-article:066a24f172fb44468bc65e725b60b53d2021-12-02T15:33:54ZMonitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software10.1038/s41467-017-02505-02041-1723https://doaj.org/article/066a24f172fb44468bc65e725b60b53d2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02505-0https://doaj.org/toc/2041-1723How gene regulatory pathways control cell fate decisions in single cells is not fully understood. Here the authors present an integrated dual-input microfluidic chip and a linked analysis software, enabling tracking of gene regulatory responses of single bacterial cells to changing conditions.Matthias KaiserFlorian JugThomas JulouSiddharth DeshpandeThomas PfohlOlin K. SilanderGene MyersErik van NimwegenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthias Kaiser Florian Jug Thomas Julou Siddharth Deshpande Thomas Pfohl Olin K. Silander Gene Myers Erik van Nimwegen Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
description	How gene regulatory pathways control cell fate decisions in single cells is not fully understood. Here the authors present an integrated dual-input microfluidic chip and a linked analysis software, enabling tracking of gene regulatory responses of single bacterial cells to changing conditions.
format	article
author	Matthias Kaiser Florian Jug Thomas Julou Siddharth Deshpande Thomas Pfohl Olin K. Silander Gene Myers Erik van Nimwegen
author_facet	Matthias Kaiser Florian Jug Thomas Julou Siddharth Deshpande Thomas Pfohl Olin K. Silander Gene Myers Erik van Nimwegen
author_sort	Matthias Kaiser
title	Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
title_short	Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
title_full	Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
title_fullStr	Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
title_full_unstemmed	Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
title_sort	monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/066a24f172fb44468bc65e725b60b53d
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Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software

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