ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

Glaucoma is the leading cause of irreversible blindness affecting over 70 million people worldwide. Here, the authors show that inhibition of chronic ER stress-induced ATF4-CHOP-GADD34 signaling pathway rescues pathology in mouse models of glaucoma, thus suggesting a possible treatment strategy.

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Detalles Bibliográficos
Autores principales: Ramesh B. Kasetti, Pinkal D. Patel, Prabhavathi Maddineni, Shruti Patil, Charles Kiehlbauch, J. Cameron Millar, Charles C. Searby, VijayKrishna Raghunathan, Val C. Sheffield, Gulab S. Zode
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/066b0588eecd45bc90ad78f0bc0e7443
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Descripción
Sumario:Glaucoma is the leading cause of irreversible blindness affecting over 70 million people worldwide. Here, the authors show that inhibition of chronic ER stress-induced ATF4-CHOP-GADD34 signaling pathway rescues pathology in mouse models of glaucoma, thus suggesting a possible treatment strategy.

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