ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

Glaucoma is the leading cause of irreversible blindness affecting over 70 million people worldwide. Here, the authors show that inhibition of chronic ER stress-induced ATF4-CHOP-GADD34 signaling pathway rescues pathology in mouse models of glaucoma, thus suggesting a possible treatment strategy.

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Autores principales:	Ramesh B. Kasetti, Pinkal D. Patel, Prabhavathi Maddineni, Shruti Patil, Charles Kiehlbauch, J. Cameron Millar, Charles C. Searby, VijayKrishna Raghunathan, Val C. Sheffield, Gulab S. Zode
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/066b0588eecd45bc90ad78f0bc0e7443
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spelling	oai:doaj.org-article:066b0588eecd45bc90ad78f0bc0e74432021-12-02T14:41:01ZATF4 leads to glaucoma by promoting protein synthesis and ER client protein load10.1038/s41467-020-19352-12041-1723https://doaj.org/article/066b0588eecd45bc90ad78f0bc0e74432020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19352-1https://doaj.org/toc/2041-1723Glaucoma is the leading cause of irreversible blindness affecting over 70 million people worldwide. Here, the authors show that inhibition of chronic ER stress-induced ATF4-CHOP-GADD34 signaling pathway rescues pathology in mouse models of glaucoma, thus suggesting a possible treatment strategy.Ramesh B. KasettiPinkal D. PatelPrabhavathi MaddineniShruti PatilCharles KiehlbauchJ. Cameron MillarCharles C. SearbyVijayKrishna RaghunathanVal C. SheffieldGulab S. ZodeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ramesh B. Kasetti Pinkal D. Patel Prabhavathi Maddineni Shruti Patil Charles Kiehlbauch J. Cameron Millar Charles C. Searby VijayKrishna Raghunathan Val C. Sheffield Gulab S. Zode ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load
description	Glaucoma is the leading cause of irreversible blindness affecting over 70 million people worldwide. Here, the authors show that inhibition of chronic ER stress-induced ATF4-CHOP-GADD34 signaling pathway rescues pathology in mouse models of glaucoma, thus suggesting a possible treatment strategy.
format	article
author	Ramesh B. Kasetti Pinkal D. Patel Prabhavathi Maddineni Shruti Patil Charles Kiehlbauch J. Cameron Millar Charles C. Searby VijayKrishna Raghunathan Val C. Sheffield Gulab S. Zode
author_facet	Ramesh B. Kasetti Pinkal D. Patel Prabhavathi Maddineni Shruti Patil Charles Kiehlbauch J. Cameron Millar Charles C. Searby VijayKrishna Raghunathan Val C. Sheffield Gulab S. Zode
author_sort	Ramesh B. Kasetti
title	ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load
title_short	ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load
title_full	ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load
title_fullStr	ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load
title_full_unstemmed	ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load
title_sort	atf4 leads to glaucoma by promoting protein synthesis and er client protein load
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/066b0588eecd45bc90ad78f0bc0e7443
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ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

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