Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3

Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3

Abstract Background Diabetes mellitus (DM), a most common chronic disease, is featured with impaired endothelial function and bioavailability of nitric oxide (NO), while E3 ubiquitin ligase appears to alleviate endothelial dysfunction as a promising option for DM treatment. Herein, we aimed to deter...

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Autores principales: Qingsong Jin, Liangyan Lin, Tiantian Zhao, Xiaoyan Yao, Yaqin Teng, Dongdong Zhang, Yongjun Jin, Meizi Yang
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Diabetes mellitus
Cbl
Endothelial dysfunction
JAK2
STAT4
Human umbilical vein endothelial cells
Medicine
R
Acceso en línea:https://doaj.org/article/066e7511a6b149e18eaa94dde577c516
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https://doaj.org/article/066e7511a6b149e18eaa94dde577c516

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