Revealing Intraosseous Blood Flow in the Human Tibia With Ultrasound

ABSTRACT Intraosseous blood circulation is thought to have a critical role in bone growth and remodeling, fracture healing, and bone disorders. However, it is rarely considered in clinical practice because of the absence of a suitable noninvasive in vivo measurement technique. In this work, we asses...

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Autores principales:	Sébastien Salles, Jami Shepherd, Hendrik J. Vos, Guillaume Renaud
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	MUSCULOSKELETAL DISEASES BONE ULTRASOUND ANALYSIS/QUANTITATION OF BONE RADIOLOGY AGING Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/0671c161687d469cbcdad18f2df16bc6
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spelling	oai:doaj.org-article:0671c161687d469cbcdad18f2df16bc62021-11-04T12:00:57ZRevealing Intraosseous Blood Flow in the Human Tibia With Ultrasound2473-403910.1002/jbm4.10543https://doaj.org/article/0671c161687d469cbcdad18f2df16bc62021-11-01T00:00:00Zhttps://doi.org/10.1002/jbm4.10543https://doaj.org/toc/2473-4039ABSTRACT Intraosseous blood circulation is thought to have a critical role in bone growth and remodeling, fracture healing, and bone disorders. However, it is rarely considered in clinical practice because of the absence of a suitable noninvasive in vivo measurement technique. In this work, we assessed blood perfusion in tibial cortical bone simultaneously with blood flow in the superficial femoral artery with ultrasound imaging in five healthy volunteers. After suppression of stationary signal with singular‐value‐decomposition, pulsatile blood flow in cortical bone tissue is revealed, following the heart rate measured in the femoral artery. Using a method combining transverse oscillations and phase‐based motion estimation, 2D vector flow was obtained in the cortex of the tibia. After spatial averaging over the cortex, the peak blood velocity along the long axis of the tibia was measured at four times larger than the peak blood velocity across the bone cortex. This suggests that blood flow in central (Haversian) canals is larger than in perforating (Volkmann's) canals, as expected from the intracortical vascular organization in humans. The peak blood velocity indicates a flow from the endosteum to the periosteum and from the heart to the foot for all subjects. Because aging and the development of bone disorders are thought to modify the direction and velocity of intracortical blood flow, their quantification is crucial. This work reports for the first time an in vivo quantification of the direction and velocity of blood flow in human cortical bone. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.Sébastien SallesJami ShepherdHendrik J. VosGuillaume RenaudWileyarticleMUSCULOSKELETAL DISEASESBONE ULTRASOUNDANALYSIS/QUANTITATION OF BONERADIOLOGYAGINGOrthopedic surgeryRD701-811Diseases of the musculoskeletal systemRC925-935ENJBMR Plus, Vol 5, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MUSCULOSKELETAL DISEASES BONE ULTRASOUND ANALYSIS/QUANTITATION OF BONE RADIOLOGY AGING Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
spellingShingle	MUSCULOSKELETAL DISEASES BONE ULTRASOUND ANALYSIS/QUANTITATION OF BONE RADIOLOGY AGING Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935 Sébastien Salles Jami Shepherd Hendrik J. Vos Guillaume Renaud Revealing Intraosseous Blood Flow in the Human Tibia With Ultrasound
description	ABSTRACT Intraosseous blood circulation is thought to have a critical role in bone growth and remodeling, fracture healing, and bone disorders. However, it is rarely considered in clinical practice because of the absence of a suitable noninvasive in vivo measurement technique. In this work, we assessed blood perfusion in tibial cortical bone simultaneously with blood flow in the superficial femoral artery with ultrasound imaging in five healthy volunteers. After suppression of stationary signal with singular‐value‐decomposition, pulsatile blood flow in cortical bone tissue is revealed, following the heart rate measured in the femoral artery. Using a method combining transverse oscillations and phase‐based motion estimation, 2D vector flow was obtained in the cortex of the tibia. After spatial averaging over the cortex, the peak blood velocity along the long axis of the tibia was measured at four times larger than the peak blood velocity across the bone cortex. This suggests that blood flow in central (Haversian) canals is larger than in perforating (Volkmann's) canals, as expected from the intracortical vascular organization in humans. The peak blood velocity indicates a flow from the endosteum to the periosteum and from the heart to the foot for all subjects. Because aging and the development of bone disorders are thought to modify the direction and velocity of intracortical blood flow, their quantification is crucial. This work reports for the first time an in vivo quantification of the direction and velocity of blood flow in human cortical bone. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
format	article
author	Sébastien Salles Jami Shepherd Hendrik J. Vos Guillaume Renaud
author_facet	Sébastien Salles Jami Shepherd Hendrik J. Vos Guillaume Renaud
author_sort	Sébastien Salles
title	Revealing Intraosseous Blood Flow in the Human Tibia With Ultrasound
title_short	Revealing Intraosseous Blood Flow in the Human Tibia With Ultrasound
title_full	Revealing Intraosseous Blood Flow in the Human Tibia With Ultrasound
title_fullStr	Revealing Intraosseous Blood Flow in the Human Tibia With Ultrasound
title_full_unstemmed	Revealing Intraosseous Blood Flow in the Human Tibia With Ultrasound
title_sort	revealing intraosseous blood flow in the human tibia with ultrasound
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/0671c161687d469cbcdad18f2df16bc6
work_keys_str_mv	AT sebastiensalles revealingintraosseousbloodflowinthehumantibiawithultrasound AT jamishepherd revealingintraosseousbloodflowinthehumantibiawithultrasound AT hendrikjvos revealingintraosseousbloodflowinthehumantibiawithultrasound AT guillaumerenaud revealingintraosseousbloodflowinthehumantibiawithultrasound
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Revealing Intraosseous Blood Flow in the Human Tibia With Ultrasound

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